Q Fever Pneumonia

Marrie, Thomas J.

doi:10.1016/j.idc.2009.10.004

Cited by 38 publications

(27 citation statements)

References 81 publications

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“…Fever and headache are the most frequent symptoms in patients with Q fever pneumonia [76]. Also extrapulmonary complications (hemophagocytosis, lymphadenopathy mimicking lymphoma, splenic rupture, neurological manifestations, pericarditis, myocarditis) were described in cases of Q fever pneumonia [76].…”

Section: Coxiella Burnetiimentioning

confidence: 99%

Community-acquired pneumonia related to intracellular pathogens

Cilloniz¹,

Niederman

Eerden

et al. 2016

Intensive Care Med

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Community-acquired pneumonia (CAP) is associated with high rates of morbidity and mortality worldwide; the annual incidence of CAP among adults in Europe has ranged from 1.5 to 1.7 per 1000 population. Intracellular bacteria are common causes of CAP. However, there is considerable variation in the reported incidence between countries and change over time. The intracellular pathogens that are well established as causes of pneumonia are Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Chlamydophila psittaci, and Coxiella burnetii. Since it is known that antibiotic treatment for severe CAP is empiric and includes coverage of typical and atypical pathogens, microbiological diagnosis bears an important relationship to prognosis of pneumonia. Factors such as adequacy of initial antibiotic or early de-escalation of therapy are important variables associated with outcomes, especially in severe cases. Intracellular pathogens sometimes appear to cause more severe disease with respiratory failure and multisystem dysfunction associated with fatal outcomes. The clinical relevance of intracellular pathogens in severe CAP has not been specifically investigated. We review the prevalence, general characteristics, and outcomes of severe CAP cases caused by intracellular pathogens.

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Section: Coxiella Burnetiimentioning

confidence: 99%

Community-acquired pneumonia related to intracellular pathogens

Cilloniz¹,

Niederman

Eerden

et al. 2016

Intensive Care Med

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“…In humans, the infection has an acute, chronic, and subclinical form (Raoult et al 2000). The epidemiology of Q fever suggests that the infection is principally transmitted by inhalation of desiccated aerosol particles and through contact with infected animals and their reproductive tissues (Marrie 2010;Maurin and Raoult 1999). Ingestion has been often suggested, particularly through the consumption of dairy products derived from contaminated raw milk and even possibly following pasteurization (Angelakis and Raoult 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Persons in contact with farm animals can be infected by inhalation of contaminated aerosols from amniotic fluid or placenta or contaminated wool (Angelakis and Raoult 2010). Pneumonia is the major manifestation of Q fever in some countries (Marrie 2010). In humans, acute infection is usually characterized by atypical pneumonia, cardiac involvement, skin rush, neurological signs, and hepatitis (Angelakis and Raoult 2010).…”

Section: Introductionmentioning

confidence: 99%

The first serologic study of Q fever in sheep in Iran

Sakhaee

Khalili

2010

Trop Anim Health Prod

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Coxiella burnetii is an obligate intracellular microorganism that causes Q fever in humans and animals. In ewes, C. burnetii infections are generally asymptomatic, but they can lead to abortions, stillbirths, and delivery of weak and unviable lambs. Serological assays are suitable for screening herds. Enzyme-linked immunosorbent assays (ELISA) technique has a high sensitivity and a good specificity. The aim of this study was to investigate the presence of anti-C. burnetii antibodies among sheep in southeast Iran. A total of 85 serum samples were collected from ten sheep flocks from April to September 2009. Serum samples were tested for Q fever antibodies using a commercial indirect ELISA kit. Antibodies were detected in 25 sera (29.42%) of 85 samples. Sixteen female (18.82%) and nine male (10.58%) cases had antibodies specific to C. burnetii. There is significant difference in seropositivity between male and female groups (P < 0.05). This first study of C. burnetii seroprevalence in sheep in southeast Iran has indicated that seropositive animals can be found throughout the country. Further work is now required to characterize the epidemiology of the infection more thoroughly.

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“…Non-infectious causes of microscopic hematuria include trauma, drug induced, GU malignancy, periarteritis nodosa, calculi, ureteral structure, hydronephrosis, renal vein thrombosis, malignant hypertension, polycystic kidney disease, renal infarction and malacoplakia. 6,7 There is only one case report of Legionnaire's Disease and gross hematuria. 8 The only two causes of communityacquired pneumonia (CAP) their have been associated with otherwise unexplained microscopic hematuria are Legionnaire's Disease and Q fever CAP.…”

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confidence: 99%

“…In our cohort of 30 Legionnaire's Disease CAPs, no other infectious or non-infectious causes of microscopic hematuria were present and none of our CAP patients had a recent zoonotic contact with cats or sheep. 6,7 The ages of 30 legionella CAP patients ranged from 38 to 87 years (19 patients were male and 11 patients were female). Microscopic hematuria was defined as >1 RBCs/hpf in a urine specimen of a non-urinary catheterized patient.…”

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confidence: 99%