Q fever.

Brown, Ginevra

doi:10.1136/bmj.2.5857.43

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…(386). It was previously observed that these cases of endocarditis affected mainly the aortic valve (387) and had a very poor prognosis, with frequent relapses after surgical valve replacement and treatment with tetracyclines alone (388). In 1978, Turck discussed the accuracy of the serological criteria for Q fever endocarditis developed by the WHO study group (389).…”

Section: Clinical Aspects Chronic Q Fever: From Historical Backgroundmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Clinical Aspects Chronic Q Fever: From Historical Backgroundmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…In animals, Q fever is rarely symptomatic, except for manifestations as reproductive disorders in females. The disease is transmitted to humans incidentally by inhalation of aerosols from infected cattle and sheep ( 1 , 2 ). In humans, C. burnetii infection may be asymptomatic, acute, or chronic.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Coxiella burnetii Infection in Dairy Cattle and Non-symptomatic People for Routine Health Screening in Korea

et al. 2006

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We report results on the seroprevalence of antibodies to Coxiella burnetii in cattle and healthy people in Korea. Upon agreement with dairy owners, serum samples from 414 dairy cattle were collected between March and June 2001 and samples from 205 people for health screening were collected between April and December 2002. The sera were analyzed for the presence of anti-C. burnetii phase II antibodies using an indirect microimmunofluorescence test; strong fluorescence at a 1:32 dilution was regarded as positive. The overall seroprevalence of C. burnetii in cattle in Korea was 25.6%, with regional variation from 8.9 to 59.3%. Of the positive serum samples, 75.5% had antibody titers ≥1:256. By contrast, only 1.5% of people in a rural area were seropositive, and most of the positive samples had low antibody titers. In conclusion, this study showed that relatively high seropositivity of C. burnetii in dairy cattle, accordingly, the studies on the high-risk groups are needed to evaluate the seroprevalence for this organism in Korea.

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“…Humans are often highly susceptible to the disease, and very few organisms may be necessary to cause infection. More information about this infectious disease is provided in [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Modeling latent spatio-temporal disease incidence using penalized composite link models

et al. 2022

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Epidemiological data are frequently recorded at coarse spatio-temporal resolutions to protect confidential information or to summarize it in a compact manner. However, the detailed patterns followed by the source data, which may be of interest to researchers and public health officials, are overlooked. We propose to use the penalized composite link model (Eilers PCH (2007)), combined with spatio-temporal P-splines methodology (Lee D.-J., Durban M (2011)) to estimate the underlying trend within data that have been aggregated not only in space, but also in time. Model estimation is carried out within a generalized linear mixed model framework, and sophisticated algorithms are used to speed up computations that otherwise would be unfeasible. The model is then used to analyze data obtained during the largest outbreak of Q-fever in the Netherlands.

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Q fever.

Cited by 7 publications

References 3 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Seroprevalence of Coxiella burnetii Infection in Dairy Cattle and Non-symptomatic People for Routine Health Screening in Korea

Modeling latent spatio-temporal disease incidence using penalized composite link models

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