Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells

Karamian, Amin; Paktinat, Shahrokh; Esfandyari, Sahar; Nazarian, Hamid; Ziai, Seyed Ali; Zarnani, Amir‐Hassan; Salehpour, Saghar; Hosseinirad, Hossein; Karamian, Armin; Novin, Marefat Ghaffari

doi:10.1177/0960327120964543

Cited by 14 publications

(11 citation statements)

References 65 publications

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“…The functions of IL-6 in kidney diseases have been well studied, its involvement and pro-inflammatory actions enhance endothelial permeability, resulting in microalbuminuria in early DN [ 28 ]. IL-8 is the pro-inflammatory chemokine responsible for the recruitment and activation of immune cells to injured endothelium [ 29 ]. The interaction of these pro-inflammatory factors leads to the development of DN.…”

Section: Discussionmentioning

confidence: 99%

Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells

Sun

Zhou

et al. 2021

Bioengineered

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Diabetic nephropathy (DN) is a common complication of diabetes. Tamsulosin is a selective α1-AR antagonist. α1-AR is expressed widely in kidney tissues and has displayed its various physiological functions. However, whether Tamsulosin has affects DN is unknown. To our knowledge, this is the first time it has been examined whether Tamsulosin possesses a beneficial effect in high glucosechallenged glomerular endothelial cells (GECs). Firstly, we found that Tamsulosin reduced high glucose-induced expressions of TNF-α, IL-6, and IL-8. Secondly, Tamsulosin alleviated high glucose-induced expressions of MMP-2 and MMP-9. Thirdly, Tamsulosin inhibited the expressions of VCAM-1 and ICAM-1. Importantly, our results indicate that Tamsulosin inhibited high glucoseinduced expressions of fibrosis factors such as Col-1 and TGF-β1. Additionally, we found that Tamsulosin ameliorated oxidative stress via reducing the generation of ROS and preventing the activation of p38. Mechanistically, we found that Tamsulosin attenuated high glucose-induced activation of NF-κB. Based on these findings, we conclude that Tamsulosin could attenuate high glucose-induced injury in GECs through alleviating oxidative stress and inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells

Sun

Zhou

et al. 2021

Bioengineered

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“…Endometriosis is an inflammatory and estrogen-dependent gynecological disorder characterized by the proliferation of endometrial cells outside the uterine cavity [ 134 ]. Indeed, endometrial cells migrate from their original site, the uterus, to other organs and produce endometrial-like tissues in various anatomical sites outside the uterine cavity, particularly the ovaries and the peritoneum [ 134 , 135 ]. Although the symptoms of endometriosis are not specific and most of them are similar to symptoms of other gynecological diseases, it may cause pelvic pain and infertility.…”

Section: Endometriosismentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

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“…IL-8 is involved in the pathological process of endometriosis. Ectopic endometrial stromal cells exhibited signi cantly increased IL-6 and IL-8 mRNA gene expression and secretion compared with orthotopic and control endometrial stromal cells prior to treatment [20].…”

Section: Discussionmentioning

confidence: 97%

Identification of differentially expressed genes and signalling pathways related to ovarian endometriosis based on integrated bioinformatic analysis

Lin

Pan

et al. 2021

Preprint

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Purpose Endometriosis is a common gynaecological disease; however, the specific mechanism and the key molecules involved in endometriosis have not been elucidated. This study aimed to identify key genes associated with poor prognosis and further uncover underlying mechanisms. Methods Data regarding mRNA expression profiles used in this study were retrieved from the Gene Expression Omnibus (GEO) database, and a total of three mRNA expression profiles were included in subsequent analyses (GSE31515, GSE58178 and GSE120103). We divided all differentially expressed genes (DEGs) into up-regulated and down-regulated groups. Then, we conducted Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) analysis using R software.Results A total of 304 DEGs were identified between endometriosis tissues and normal endometrium tissues using integrated analysis, including 185 up-regulated genes and 119 down-regulated genes. GO analysis revealed that the up-regulated DEGs of endometriosis were closely associated with voltage-gated calcium channel activity, whereas the down-regulated DEGs were enriched in uterus development. KEGG pathway enrichment analysis indicated that the up-regulated DEGs were mainly involved in cytokine-cytokine receptor interaction, whereas down-regulated DEGs were enriched in protein processing in the endoplasmic reticulum. In addition, PPIs of these DEGs were visualized using the Cytoscape platform and the Search Tool for the Retrieval of Interacting Genes (STRING). PPI analysis identified 10 potential DEG-related protein targets, including CCND1, IL6, CCL2, COL1A2, PTGS2, VCAM1, COL3A1, ELN, SERPINE1, and HSP90B1. Conclusion In conclusion, the present study reveals that voltage-gated calcium channel activity, uterus development, cytokine-cytokine receptor interaction and protein processing in the endoplasmic reticulum may be involved in the development of endometriosis. In addition, these identified DEGs may exhibit clinical significance for the diagnosis and treatment of endometriosis.

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Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells

Cited by 14 publications

References 65 publications

Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells

Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells

Nutrition in Gynecological Diseases: Current Perspectives

Identification of differentially expressed genes and signalling pathways related to ovarian endometriosis based on integrated bioinformatic analysis

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