Pyoderma gangrenosum in childhood - the importance of early recognition

Pediatric Pyoderma Gangrenosum: A Retrospective Review of Clinical Features, Etiologic Associations, and Treatment

“…In children, IBD has been the most commonly reported comorbidity in patients with PG, with ulcerative colitis often reported . Other commonly associated diseases in children are arthritis and leukemia . Our findings support the close association between IBD and pediatric PG, although CD was more commonly seen in our cohort.…”

“…As in the study by Graham et al (9), the anatomic distribution of lesions in our patients was fairly even, with much greater head and neck involvement than in classic adult PG (in which the disease is most likely to develop on the lower extremities). Early recognition of facial PG is imperative because the natural course of PG frequently leads to cribriform scarring (10). Pathergy was common in the study by Graham et al (9) and was seen in 62% of our patients, which is a much larger proportion than described in the adult population (11).…”

CD30+ anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines

“…ALCL is a NHL characterised by peculiar pathological features in that the tumor cells have large pleomorphic nuclei and are positive for CD30 (Ki‐1) antigen. PG mimics benign dermatosis with marked infiltration of neutrophils and involvement of thrombosis in small vessels often associated with underlying systemic disease (1–4). Because of the subsequent and recurrent dermatosis, it is suggested that PG is one of the skin lesions associated with ALCL.…”

“…PG is commonly associated with systemic diseases, such as autoimmune and myeloproliferative disorders (1, 2). Although the condition is seen in patients of all ages, children account for only 3–4% of the total incidence (3, 4). Anaplastic large cell lymphoma (ALCL) is a relatively rare disease in children with malignant non‐Hodgkin's lymphomas (NHLs) (5).…”