Pyoderma gangrenosum in a patient with HTLV-III antibody

Schwartz, B. K.

doi:10.1001/archderm.122.5.508

Cited by 7 publications

(5 citation statements)

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“…PG was once considered pathognomonic of ulcerative colitis. However, it has since been described in association with a wide variety of disorders [5], including Crohn disease, arthritis, rheumatologic and hematological conditions [14, 15], HIV infection [16], sarcoidosis [6], hereditary hypogammaglobulinemia [17], iatrogenic immune suppression [18] and malignancy [5], the onset of which may precede, coincide, or follow the onset of PG. Six of our 18 cases (33%) had associated diseases (Tables 1, 4).…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum: Clinical presentation and outcome in 18 cases and review of the literature

Hasselmann

Bens

Tilgen

et al. 2007

J Deutsche Derma Gesell

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Our observations add to the growing body of evidence that PG responds in most cases to systemic immunosuppressive treatment, with corticosteroids and cyclosporine representing first-line therapies. Besides reporting the clinical outcome in our 18 patients, we review the literature and discuss treatment recommendations that take additional factors including associated conditions, disease severity and localization of lesions into consideration.

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Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum: Clinical presentation and outcome in 18 cases and review of the literature

Hasselmann

Bens

Tilgen

et al. 2007

J Deutsche Derma Gesell

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“…First described in 1930 by Brunsting et al, 1 pyoderma gangrenosum (PG) is an idiopathic neutrophilic dermatosis that was once considered pathognomonic of idiopathic ulcerative colitis. It has since been described in association with a wide variety of disorders, including Crohn's disease, diverticulitis, hematological and rheumatological conditions, hepatopathies, visceral carcinomata, and states of perturbed immune function such as human immunodeficiency virus (HIV) and HTLV‐III infection, 2 sarcoidosis, 3 hereditary hypogammaglobulinemia, 4 and iatrogenic immune suppression 4–9 (see Table 1). Roughly 50–70% of cases of PG are associated with an underlying systemic disease 10–12 .…”

Section: Disorders Associated With Pyoderma Gangrenosum (After Wines mentioning

confidence: 99%

Pyoderma gangrenosum: a review

2003

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Since its first description in 1930, the pathogenesis of pyoderma gangrenosum (PG) has remained obscure even as an ever-widening array of systemic diseases has been described in association with it. The histopathologic distinction of PG from other ulcerative processes with dermal neutrophilia is challenging and at times impossible. In consequence, when confronted with a biopsy from such a lesion, the pathologist has an obligation to obtain a full and detailed clinical history. In short, as a diagnosis of PG does not hinge exclusively upon the biopsy findings in isolation from other studies, a solid knowledge of the clinical features, the systemic disease associations and the differential diagnosis will help the pathologist to avoid diagnostic pitfalls or the generation of a report which is non-contributory to patient care. In this review, we describe in detail the different clinicopathologic forms of PG, summarize the diseases associated with this process in the literature and in our experience, and briefly review the treatment options.

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“…P yoderma gangrenosum (PG) was once considered pathognomonic of idiopathic ulcerative colitis. It has since been described in association with a wide variety of disorders, 1,2 including Crohn's disease, arthritis, rheumatologic and hematologic conditions, 3,4 HIV infection, 5 sarcoidosis, 6 hereditary hypogammaglobulinemia, 7 iatrogenic immune suppression, 8 or malignancy. 1,2 The pathogenesis is unknown, but autoimmune mechanisms including immune complexemediated neutrophilic vascular reactions have been suggested.…”

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confidence: 99%