Pyoderma Gangrenosum Associated with Hypogammaglobulinemia

Bloom, David

doi:10.1001/archderm.1958.01560040036006

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Pyoderma Gangrenosum1

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1964

2017

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Cited by 25 publications

(14 citation statements)

References 4 publications

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“…One group, of 10 patients, had various intestinal disorders (one of them suffered from ileitis rcgionalis [24,49,26,4,16,31,40,29,61].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β<sub>2</sub>A-paraprotein)

Sluis¹

1966

Dermatology

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“…One group, of 10 patients, had various intestinal disorders (one of them suffered from ileitis rcgionalis [24,49,26,4,16,31,40,29,61].…”

mentioning

confidence: 99%

“…In the second group, there is one patient with extrem ely low [4] and one with an elevated y-globulin level [16].…”

mentioning

confidence: 99%

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β<sub>2</sub>A-paraprotein)

Sluis¹

1966

Dermatology

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“…It was also clear that it was possible to reduce other treatments when the lesions had healed and to discontinue hdIGIV. Improvement of PG in the setting of hypogammaglobulinemia has also been described with replacement IGIV [44,45]. The mechanism of action is not clear; however, it is possible that effects of hdIGIV on the local cytokine environment (e.g.…”

Section: Pyoderma Gangrenosummentioning

confidence: 99%

Use of IGIV in the treatment of atopic dermatitis, urticaria, scleromyxedema, pyoderma gangrenosum, psoriasis, and pretibial myxedema

Jolles

Hughes

2006

International Immunopharmacology

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“…PG is a neutrophilic dermatosis that occurs both as a primary disorder as well as secondary to an underlying disease. To date, only five previous reports have documented the association of PG with XLA56789. We report herein a case of PG in a patient with XLA.…”

Section: Introductionmentioning

confidence: 99%

Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia

2017

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X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder caused by germline mutations of B-cell tyrosine kinase (BTK) gene. It is characterized by decreased serum immunoglobulins levels and circulating mature B cells. This defect in humoral immunity leads to increased susceptibility to infection. Pyoderma gangrenosum (PG) is an uncommon, ulcerating, neutrophilic dermatosis. Here we report PG in an 8-year-old patient with XLA. The patient received intravenous immunoglobulin treatment in conjunction with prednisone and topical application of 0.03% tacrolimus ointment and the ulcer was almost completely healed in the 2 weeks of follow-up. The coexistence has been rarely reported. XLA may be a possible cofactor in the pathogenesis of PG.

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Pyoderma Gangrenosum Associated with Hypogammaglobulinemia

Cited by 25 publications

References 4 publications

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β<sub>2</sub>A-paraprotein)

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β<sub>2</sub>A-paraprotein)

Use of IGIV in the treatment of atopic dermatitis, urticaria, scleromyxedema, pyoderma gangrenosum, psoriasis, and pretibial myxedema

Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia

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