Pyoderma gangrenosum and monoclonal gammopathy

Powell, F. C.

doi:10.1001/archderm.119.6.468

Cited by 42 publications

(24 citation statements)

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“…The causal relationship between monoclonal gammopathy and PG is not established, and the incidence of the association varies among studies. Powell et al 12 report that 9 of 86 patients with PG had monoclonal gammopathy: 7 had IgA paraprotein, 1 had immunoglobulin G (IgG), and 1 had immunoglobulin M (IgM). Prystowsky et al 13 reviewed 21 patients with PG, 4 of whom had IgA monoclonal gammopathy.…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum with necrotizing sclerokeratitis after cataract surgery

Fournié¹,

Malecaze²,

Coullet³

et al. 2007

Journal of Cataract and Refractive Surgery

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A 78-year-old man who had had uneventful extracapsular cataract extraction in the left eye 3 months earlier developed pyoderma gangrenosum (PG)-associated peripheral ulcerative keratitis (PUK) after suture removal. The patient had a 13-year history of PG associated with monoclonal immunoglobulin-A gammopathy. He presented with extensive, painful PUK at the incision site, with a descemetocele and a high risk for perforation. Fibrin glue tissue adhesive was used to stabilize the corneal ulcer as an adjunct to topical and systemic treatment. The patient had been treated with tapering doses of prednisone and cyclophosphamide (50 mg/day). High-dose human intravenous immunoglobulin (0.4 mg/kg/d for 4 days) was administered. The ulcer healed 1 month later with a loss of visual acuity. To our knowledge, this is the first reported case of PG-associated sclerokeratitis following cataract surgery. Early recognition of this rare ocular localization of PG is important to institute the appropriate therapy.

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Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum with necrotizing sclerokeratitis after cataract surgery

Fournié¹,

Malecaze²,

Coullet³

et al. 2007

Journal of Cataract and Refractive Surgery

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“…There is a well-described association between monoclonal gammopathy and another dermatitis, pyoderma gangrenosum [11, 12, 13, 14]. This is a rare condition that has classically been linked to inflammatory gastrointestinal disorders such as ulcerative colitis; however, it has also been found to be associated with rheumatoid arthritis, monoclonal gammopathies and occasionally lymphomas and leukemias.…”

Section: Discussionmentioning

confidence: 99%

Migratory Necrolytic Dermatitis Presenting after Cephalosporin Administration in a Patient with a Pancreatic Head Mass

Gumbs

Parisi²,

Sargenti³

et al. 2004

Dig Surg

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Migratory necrotizing dermatitis is one of the most distressing presenting symptoms of glucagonomas. This rare functioning pancreatic endocrine tumor is third in incidence after insulinomas and gastrinomas and is often malignant at the time of diagnosis. Elevated serum glucagon levels cause decreased amino acid levels which is believed to be the principal cause of the dermatitis. Other symptoms include anemia, visual scotomata and mild diabetes mellitus. Medical treatment alone including octreotide and amino acid supplementation has been reported to eliminate the dermatitis. Nonetheless, surgical resection or debulking remains the definitive treatment when possible. Because of its rarity, diagnosis may be delayed by years accounting for the high rate of metastasis at presentation. Reported here is the case of a 77-year-old man who presented with a migratory necrotizing dermatitis after antibiotic treatment and whose diagnosis of a glucagonoma was then delayed for over 1 year.

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“…PG has been associated commonly with inflammatory bowel disease, arthritis, malignant disorders and monoclonal gammopathy, usually IgA [10, 11, 12, 13, 14, 15, 16, 17]. PG has rarely been reported in patients with SLE [12, 22, 23, 24, 25], SLE with secondary antiphospholipid antibody syndrome [20, 21]or patients with primary antiphospholipid antibody syndrome [19, 26].…”

Section: Commentmentioning

confidence: 99%

“…PG has been associated most commonly with inflammatory bowel disease, arthritis and hematologic premalignant or malignant disorders [10, 11, 12, 13, 14, 15, 16, 17]. Although PG-like ulceration has been reported in patients with the antiphospholipid antibody syndrome, PG has rarely been reported in patients with SLE [18, 19, 20, 21, 22, 23, 24, 25, 26].…”

Section: Introductionmentioning

confidence: 99%

Pyoderma gangrenosum Preceding the Diagnosis of Systemic Lupus erythematosus

Waldman

Callen²

2005

Dermatology

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Patients with systemic lupus erythematosus (SLE) often develop leg ulceration, particularly those with antiphospholipid antibodies or with vasculitis. Pyoderma gangrenosum (PG) is an idiopathic ulcerative neutrophilic dermatosis that is commonly associated with inflammatory bowel disease or seronegative polyarthritis. Although PG-like lesions have been commonly described in patients with the antiphospholipid antibody syndrome, the occurrence of PG as a preceding manifestation of SLE has only rarely been reported. We present a patient who developed PG roughly 8 years prior to developing SLE.

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Pyoderma gangrenosum and monoclonal gammopathy

Cited by 42 publications

References 0 publications

Pyoderma gangrenosum with necrotizing sclerokeratitis after cataract surgery

Pyoderma gangrenosum with necrotizing sclerokeratitis after cataract surgery

Migratory Necrolytic Dermatitis Presenting after Cephalosporin Administration in a Patient with a Pancreatic Head Mass

Pyoderma gangrenosum Preceding the Diagnosis of Systemic Lupus erythematosus

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