1972
DOI: 10.1001/archderm.105.1.46
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Pyoderma gangrenosum, altered delayed hypersensitivity and polyarthritis

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Cited by 38 publications
(15 citation statements)
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“…In most cases it has been related to an autoimmune process such as ulcerative colitis [2,3] and various forms of arthritis [4,5], The disease was considered by some to be a localized Shwartzman phenomenon [6,7] and others assumed it to be a hyperergic reaction against bacterial lipopolysaccharides [8], Long and Uesu [9] observed, in 2 patients with the disease, rejection of an autoskin and a delayed hypersensitivity to intradermal injection of the patients own leukocytes. Changes similar to those seen in acute reaction to skin graft rejection have been observed on biopsy and indirect immunofluorescence study [10] and were reported to be characteristic features in a review of 117 cases with the process [4], On the other hand, Lazarus et al [11] demonstrated an anergic-delayed hypersensitivity reaction in 4 patients with pyoderma gangrenosum and also reported a dissociation between macro phage inhibitory factor production and the blastogénie response, which may indicate a partial defect in cellular immunity. Bourgeois-Spinasse et a i [12] reported, likewise, a case revealing negative tuberculin and mumps intra dermal tests as well as lymphocyte blastogenesis at a lower level of normal.…”
Section: Discussionmentioning
confidence: 94%
“…In most cases it has been related to an autoimmune process such as ulcerative colitis [2,3] and various forms of arthritis [4,5], The disease was considered by some to be a localized Shwartzman phenomenon [6,7] and others assumed it to be a hyperergic reaction against bacterial lipopolysaccharides [8], Long and Uesu [9] observed, in 2 patients with the disease, rejection of an autoskin and a delayed hypersensitivity to intradermal injection of the patients own leukocytes. Changes similar to those seen in acute reaction to skin graft rejection have been observed on biopsy and indirect immunofluorescence study [10] and were reported to be characteristic features in a review of 117 cases with the process [4], On the other hand, Lazarus et al [11] demonstrated an anergic-delayed hypersensitivity reaction in 4 patients with pyoderma gangrenosum and also reported a dissociation between macro phage inhibitory factor production and the blastogénie response, which may indicate a partial defect in cellular immunity. Bourgeois-Spinasse et a i [12] reported, likewise, a case revealing negative tuberculin and mumps intra dermal tests as well as lymphocyte blastogenesis at a lower level of normal.…”
Section: Discussionmentioning
confidence: 94%
“…Although the exact pathogenesis of the pathergy skin reaction has yet to be fully elucidated, and may vary depending on the disease process involved, it is thought to be an immune-mediated reaction that is T-cell mediated and in some ways parallels the delayed-type hypersensitivity reaction. [27][28][29] It is most commonly associated with pyoderma gangrenosum, Sweet syndrome, lichen planus, and Behçet disease. [30][31][32][33] There have been previous reports of keratoacanthomas arising acutely in sites of recent surgical trauma, [34][35][36] and it is reasonable to posit that some of our cases may represent keratoacanthomas.…”
Section: Discussionmentioning
confidence: 99%
“…However, it was considered an element reinforcing the diagnosis of PG by excluding certain similar pathologies [2]. Based upon these requirements, 10 cases were excluded from this review [6,[12][13][14][15]. The following Prisma Flow Chart exhibits the selection methodology (Fig.…”
Section: Search Strategymentioning
confidence: 99%