Pyoderma Gangrenosum

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β₂A-paraprotein)

“…The last group, of 54 patients, had no intestinal disorders [22,66,37,18,51,19,23,46,21,72,44,35,33,25,47,74,67,43,65,55,1,53,58,28,5,36,50,57,69,63,41,31,62,29], I. (a) The association o f pyoderma gangraenosum and arthritis in the patients with colitis ulcerosa.…”

Pyoderma gangrenosum: From historical perspectives to emerging investigations

“…31 The cause of UC itself had several different considerations then, notably including infection, and the idea of a primarily infectious, bacterial aetiology for PG continued to prevail through the 1950s. 20,21,32,33 F I G U R E 3 Landmark 1930 case series describing and naming pyoderma gangrenosum (PG) 10…”

“…Arthus) hypersensitivity reaction. 20 In 1956, Wright and Greco 33 reported the first case of PG successfully treated with systemic corticosteroids. At the time, it was understood that the use of corticosteroids in the setting of active infection was detrimental, so Wright and Greco argued that PG was not, in fact, caused primarily by infection.…”

“…They instead suggested a "violent antigen-antibody reaction" for which cortisone was beneficial through its antiinflammatory actions, specifically depression of antibody formation. 33 By the 1960s, given the overall ineffectiveness of antibiotic therapy in contrast to treatment successes with corticosteroids, immunological considerations for PG became popular. By the 1970s, changes in humoral factors, cellmediated immunity, and/or neutrophil function were thought to be the cause of PG.…”

Pseudomonas Aeruginosa—Contaminant or Pathogen?

“…Such a hypothesis for the production of pyoderma gangrenosum might also ex¬ plain the beneficial effect of cortisone in this disease. 11 In the 9 cases of clinical infection with…”