"Pyoderma (ecthyma) gangrenosum" by Brunsting, Goeckerman and O'Leary, October 1930. Commentary: Pyoderma gangrenosum

Newell, Larry M.

doi:10.1001/archderm.118.10.743

Cited by 30 publications

(6 citation statements)

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“…The ulcer often starts as a pustule that rapidly progresses to ulceration. There may be single or multiple lesions, and the lower extremities are the most commonly involved location [11, 12, 13, 14, 15, 16]. Accompanying symptoms may include fever, malaise and myalgias.…”

Section: Commentmentioning

confidence: 99%

“…Accompanying symptoms may include fever, malaise and myalgias. Pathergy, trauma-induced lesions, may occur in up to 50% of patients with PG and is thought very suggestive of the diagnoses of PG [11, 14, 15, 16]. PG is a diagnosis of exclusion with nonspecific histologic and laboratory evaluations; however, a positive p-ANCA may be present, especially in those patients with inflammatory bowel disease [10].…”

Section: Commentmentioning

confidence: 99%

“…PG has been associated commonly with inflammatory bowel disease, arthritis, malignant disorders and monoclonal gammopathy, usually IgA [10, 11, 12, 13, 14, 15, 16, 17]. PG has rarely been reported in patients with SLE [12, 22, 23, 24, 25], SLE with secondary antiphospholipid antibody syndrome [20, 21]or patients with primary antiphospholipid antibody syndrome [19, 26].…”

Section: Commentmentioning

confidence: 99%

“…PG has been associated most commonly with inflammatory bowel disease, arthritis and hematologic premalignant or malignant disorders [10, 11, 12, 13, 14, 15, 16, 17]. Although PG-like ulceration has been reported in patients with the antiphospholipid antibody syndrome, PG has rarely been reported in patients with SLE [18, 19, 20, 21, 22, 23, 24, 25, 26].…”

Section: Introductionmentioning

confidence: 99%

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Pyoderma gangrenosum Preceding the Diagnosis of Systemic Lupus erythematosus

Waldman

Callen²

2005

Dermatology

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Patients with systemic lupus erythematosus (SLE) often develop leg ulceration, particularly those with antiphospholipid antibodies or with vasculitis. Pyoderma gangrenosum (PG) is an idiopathic ulcerative neutrophilic dermatosis that is commonly associated with inflammatory bowel disease or seronegative polyarthritis. Although PG-like lesions have been commonly described in patients with the antiphospholipid antibody syndrome, the occurrence of PG as a preceding manifestation of SLE has only rarely been reported. We present a patient who developed PG roughly 8 years prior to developing SLE.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pyoderma gangrenosum Preceding the Diagnosis of Systemic Lupus erythematosus

Waldman

Callen²

2005

Dermatology

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“…Although some authors believe that this treatment is ineffective [4], a good recovery has been described in single cases. In 1974, Peachey [5] reported 1 case of PG of the scalp with a good response to topically applied 0.1% betamethasone 17-valerate lotion under occlusion.…”

Section: Topical Treatmentmentioning

confidence: 99%

Topical Treatment of Pyoderma gangraenosum

et al. 2002

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The treatment of pyoderma gangraenosum (PG) is still a therapeutic challenge. Although several drugs such as corticosteroids, dapsone, clofazimine, azathioprine, tacrolimus and cyclosporine A have been shown to be effective in this disease, side-effects of these agents limit their systemic use in seriously ill patients. In recent years, topical treatment of the disease has gained attention. Several reports show an improvement of cutaneous lesions of PG following topical treatment. These earlier reports as well as our own observations suggest that topical therapeutic regimens can be a useful and safe alternative to systemic immunosuppressive therapy in the treatment of PG. We give a review about these topically used drugs and the mechanisms probably involved.

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