PWE-173 Peripheral And Central Effects Of A Single Dose Of The Glucagon-like Peptide-1 Receptor Agonist Exenatide

Wasse, Lucy K.; Little, Tanya J.; Coulson, Tessa; Bryant, C; McKie, Shane; McLaughlin, John

doi:10.1136/gutjnl-2014-307263.433

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2018

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“…8,9,12,23 In contrast, the physiological role of endogenous GLP-1 in the central regulation of appetite has rarely been investigated. 8,9,12,23 In contrast, the physiological role of endogenous GLP-1 in the central regulation of appetite has rarely been investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral infusion of GLP-1 or GLP-1 agonists can affect brain activity in areas involved in the regulation of appetite, including hypothalamic regions, as well as reward-related brain regions. 8,9,12,23 In contrast, the physiological role of endogenous GLP-1 in the central regulation of appetite has rarely been investigated. We used an experimental paradigm in which healthy lean subjects received an intragastric (ig) glucose load, with or without concomitant intravenous (iv) exendin9-39, and investigated the effect on functional connectivity between homeostatic-and reward-related brain regions, as well as on glycaemic control and appetite-related sensations.…”

Section: Discussionmentioning

confidence: 99%

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