Putty-like bone fillers based on CaP ceramics or Biosilicate® combined with carboxymethylcellulose: Characterization, optimization, and evaluation

Abstract

Calcium phosphates and bioactive glass ceramics have been considered promising biomaterials for use in surgeries. However, their moldability should be further enhanced. We here thereby report the handling, physicochemical features, and morphological characteristics of formulations consisting of carboxymethylcellulose-glycerol and hydroxyapatite-tricalcium phosphate or Biosilicate® particles. We hypothesized that combining either material with carboxymethylcellulose-glycerol would improve handling properties, retaining their bioactivity. In addition to scanning electron microscopy, cohesion, mineralization, pH, and viscoelastic properties of the novel formulations, cell culture experiments were performed to evaluate the cytotoxicity and cell proliferation. Putty-like formulations were obtained with improved cohesion and moldability. Remarkably, mineralization in simulated body fluid of hydroxyapatite-tricalcium phosphate/carboxymethylcellulose-glycerol formulations was enhanced compared to pure hydroxyapatite-tricalcium phosphate. Cell experiments showed that all formulations were noncytotoxic and that HA-TCP60 and BGC50 extracts led to an increased cell proliferation. We conclude that combining carboxymethylcellulose-glycerol with either hydroxyapatite-tricalcium phosphate or Biosilicate® allows for the generation of moldable putties, improves handling properties, and retains the ceramic bioactivity.

Remineralizing Potential of Bioactive Glass–Ceramic over White Spot Lesions

“…Bio particles are highly bioactive and undergo a rapid multistage surface reaction when in contact with an aqueous media, ultimately resulting in the formation of hydroxycarbonate apatite. 15 Therefore, ET with Bio was not formulated with water or simulated body fluid; instead, it was formulated with CMC and glycerin as a vehicle 28 and was exposed to water only immediately before the simulated brushing. Furthermore, despite their high bioactivity, Bio particles take some time to completely dissolve, as observed in a previous study 29 and confirmed in our study through SEM analysis.…”

Development and evaluation of reparative tricalcium silicate‐ZrO2‐Biosilicate composites

“…16 Although bioglasses have bioactivity, the handling properties of these materials for clinical use are limited. 17 Therefore, the association of Biosilicate powder with a hydrosoluble polymer 18 and carboxymethylcellulose 17 have been proposed in order to improve consistency and applicability.…”

Efeito da adição de vitrocerâmica bioativa em dentifrício sobre abrasividade e remineralização do esmalte dental

“…GABBAI-ARMELIN et al, 2017). Os vidros têm se mostrado promissores para a formação da hidroxiapatita ou fluoroapatita, como demonstrado em vários estudos (GJORGIEVSKA et al, 2013;KOHDA et al, 2015;MEHTA et al,.…”