Purpura fulminans and transient protein C and S deficiency

Dominey, A.

doi:10.1001/archderm.124.9.1442b

Cited by 6 publications

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“…Interestingly, the most frequent viral infection associated with acquired purpura fulminans is varicella [42]. In two patients with this illness, reduced levels of protein C and protein S have been detected during the acute phase that became normal in the convalescence [45,46]. Recent reports have described a boy with varicella, purpura fulminans, a lupus anticoagulant and transitory severe protein S deficiency [48], and the occurrence, during recovery from varicella, of severe thromboembolic disease in a boy with a transient isolated deficiency of protein S due to the presence of a circulating autoantibody to protein S [41].…”

Section: Discussionmentioning

confidence: 99%

Deep vein thrombosis in a 13‐year‐old boy with hereditary protein S deficiency and a review of the pediatric literature

et al. 1994

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We report a 13-year-old boy with hereditary deficiency of protein S, who developed a deep vein thrombosis of the lower limb after a varicella with severe cutaneous lesions. Hereditary protein S deficiency is an established cause of thrombophilia; however thrombotic events are seldom described in pediatric patients. A review of previous literature revealed 35 cases, 16 girls and 19 boys, with a first episode below of the age of 18 years old (x = 10y). The 57% of the patients had venous thrombosis, 20% arterial thrombosis, and 14% both and in 9% the type of thrombosis was not reported. Predisposing factors were referred in only 12 cases. The deficiencies can be classified as type I in 25 patients and type III in 8.

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