Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg

Roegge, Cindy S.; Morris, John R.; Villareal, Sherilyn; Wang, Victor; Powers, Brian E.; Klintsova, Anna Y.; Greenough, William T.; Pessah, Isaac N.; Schantz, Susan L.

doi:10.1016/j.ntt.2005.10.001

Cited by 69 publications

(61 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also other in vivo studies using behavioural endpoints: motoric functions [39,60], spatial memory functions [37], open-field behaviour [38] provided no proof of a synergistic or additive PCB/MeHg interaction. The only results suggesting a synergistic type of PCB (PCB 153,126) and MeHg interaction come from the Fisher et al [61] study on mice with the use of the open-field test.…”

Section: Effects Of Combined Exposure To Mehg and Pcb 153mentioning

confidence: 98%

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Sitarek¹,

Gralewicz²

2009

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental pollutants and food contaminants. Both are neurotoxic, especially for the developing nervous system. Material and Methods: Female rats were exposed from day 7 of pregnancy up to day 21 after the delivery to MeHg in drinking water, PCB 153 per os or MeHg+PCB 153. Assessment of the exposure effects in mothers included food and water intake, body weight and reproduction success. Assessment of the progeny comprised determination of body weight, time of pinna detachment, eye opening, incisor eruption, and the negative geotaxis, grip strength and righting reflex. Results: The following effects of the exposures were observed: A) MeHg: 0.5 mg/kg/day -no effect on maternal health status and reproduction. In the progeny: faster incisor eruption and hastened negative geotaxis development. MeHg 2.0 mg/kg/day: In mothers: signs of MeHg toxicity (reduced food intake and body weight, ataxia) during lactation. In the progeny: reduced rate of body weight increase, accelerated incisor eruption but delayed development of the righting reflex. B) PCB 153 exposure: 1.0 mg/kg/day: no effect on maternal health status, reproduction success or morphological and physical development of the progeny; 5.0 mg/kg/day: no effect on maternal health status and reproduction. In the progeny: accelerated growth in females, faster pinna detachment and incisor eruption but delayed development of the grip strength. C) MeHg+PCB153 exposure: none overt effect was noted in mothers or in their progeny. Conclusion: The results confirm the ability of a low level perinatal exposure to MeHg or PCB 153 to affect the early development in the rat. They have not provided, however, an evidence of a synergistic interaction of these contaminants. To the contrary, the results suggest that, at least under the conditions prevailing in the present study, MeHg and PCB 153 interact antagonistically.

show abstract

Section: Effects Of Combined Exposure To Mehg and Pcb 153mentioning

confidence: 98%

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Sitarek¹,

Gralewicz²

2009

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Many animal studies demonstrate that high dose PCB impairs neurodevelopment or their hydroxylated metabolites may interfere with thyroid hormone-dependent neurodevelopment (Kimura-Kuroda et al, 2007;Nguon et al, 2005;Purkey et al, 2004;Roegge et al, 2006).…”

Section: Geometric Selected Percentilesmentioning

confidence: 99%

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

Huber

Blount

Mage

et al. 2010

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

“…Based on the in vitro observations quoted above, some authors presume that the differences between the Seychelles and Faroe Island studies could be a consequence of the co-presence of PCBs and MeHg in the diet of the Faroe group [10,11]. Experimental in vivo studies performed so far provided no definitive confirmation or negation of this supposition [12,13]. The experiments described in the present paper are a part of a larger study, performed as part of the DEVNERTOX project sponsored by the EU Commission (DEVNER-TOX, Contract No.…”

Section: Exposure and Exposure Controlmentioning

confidence: 98%

Neurobehavioural functions in adult progeny of rat mothers exposed to methylmercury or 2,2', 4,4', 5,5'-hexachlorobiphenyl (PCB 153) alone or their combination during gestation and lactation

Gralewicz¹,

Wiaderna²,

Lutz³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants. Both are neurotoxic, especially for the developing brain. The main source of human exposure to MeHg and PCBs is seafood. The aim of the present work was to find out whether and how separate or combined perinatal exposure to these neurotoxicants affects neurobehavioural functions in maturity. Materials and Methods: The study was performed on adult Wistar rats, the progeny of rat mothers exposed to MeHg (0.5 mg/kg/day or 2.0 mg/kg/day), PCB 153 (1.0 mg/kg/day or 5.0 mg/kg/day), or to MeHg 0.5 mg/kg/day + PCB 153 5.0 mg/kg/day, from day 7 of pregnancy to day 21 post partum. The following functions were assessed: spontaneous locomotor activity (open field test), spatial short-term memory (radial maze test), long-term memory (passive avoidance test), sensitivity to pain and vulnerability to stress (hot plate test), efficiency of the sensorimotor gating (startle response test), and sensorimotor coordination (the rotarod test). Results:The results obtained in the MeHg part of the study showed a reduced locomotor activity in the female progeny of both exposed groups, an impaired passive avoidance in the male progeny of the high and low exposure group and a faster recovery from the effects of the stressful experience (hot plate test) in the male progeny of the high dose group. Results obtained in the PCB part showed an increased locomotor activity in the female progeny of both exposure groups and impairment in rotarod performance in males of the high dose group. Neurobehavioural alterations were not found in either the females or males exposed jointly to MeHg and PCB 153. Conclusions: The results suggest that in condition of the combined exposure, MeHg may protect against the effects of PCB 153 and vice versa.

show abstract

Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg

Cited by 69 publications

References 87 publications

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

Neurobehavioural functions in adult progeny of rat mothers exposed to methylmercury or 2,2', 4,4', 5,5'-hexachlorobiphenyl (PCB 153) alone or their combination during gestation and lactation

Contact Info

Product

Resources

About