Purinoceptors: Ontogeny and phylogeny

Burnstock, Geoffrey

doi:10.1002/(sici)1098-2299(199611/12)39:3/4<204::aid-ddr2>3.0.co;2-v

Cited by 108 publications

(76 citation statements)

References 385 publications

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“…ATP is a cotransmitter in many nerve types, probably reflecting the early evolutionary presence of purinergic signaling (Burnstock, 1996a(Burnstock, , 2004. There is evidence for the action of ATP as a cotransmitter with NA and neuropeptide Y in sympathetic nerves, with acetylcholine and vasoactive intestinal peptide in some parasympathetic nerves, with NO and vasoactive intestinal peptide in enteric NANC inhibitory nerves, and with calcitonin gene-related peptide (CGRP) and substance P in senso-PATHOPHYSIOLOGY AND THERAPEUTIC POTENTIAL OF PURINERGIC SIGNALING ry-motor nerves.…”

Section: Neurologymentioning

confidence: 99%

Pathophysiology and Therapeutic Potential of Purinergic Signaling

2006

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Section: Neurologymentioning

confidence: 99%

Pathophysiology and Therapeutic Potential of Purinergic Signaling

2006

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“…Purinoceptors are divided into two major families (2,4,9,(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Extracellular adenosine exerts its effects through activation of G protein-coupled, P1 receptors, which are broadly divided into four major subtypes (A1, A2A, A2B and A3 receptors) (9,(41)(42)(43)(44)47).…”

Section: Receptors and Intracellular Signalingmentioning

confidence: 99%

Role of Interstitial ATP and Adenosine in the Regulation of Renal Hemodynamics and Microvascular Function

2004

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“…The last decade has seen an increase in our understanding of the functions of purinergic signaling during development of the nervous system, including progenitor cell proliferation, cell migration, neuronal and glial maturation and differentiation, and cell death and survival [3][4][5]. P2 purinoceptors are composed of two major families: a P2X family of ligand-gated ion channel receptors (P2X1-7) and a P2Y family of G protein-coupled receptors (P2Y1, 2, 4, 6, 11, 12, 13, and 14) [6].…”

Section: Introductionmentioning

confidence: 99%

Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems

Guo

Zhang

Liu

et al. 2012

Purinergic Signalling

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The functions of P2X purinoceptors (P2X1-7) in the nervous system of adults have been widely studied. However, little is known about their roles during embryonic development. Our previous work has reported an extensive expression of P2X5 receptors in the adult mouse central nervous system. In the present study, we have examined the expression pattern of P2X5 receptor mRNA and protein during prenatal development of the mouse nervous system (from embryonic day E8 to E17). P2X5 receptors appeared in the neural tube as early as E8 and were gradually confined to new-born neurons in the cortical plate and ventral horn of the spinal cord. Heavy signals for P2X5 receptors were also found in dorsal root ganglia (DRG), retina, olfactory epithelium, and nerve fibers in skeletal muscles. In conclusion, P2X5 receptors were strongly represented in the developing mouse nervous system. The transient high expression pattern of P2X5 receptors in epithelium-like structures suggests a role during early neurogenesis.

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Purinoceptors: Ontogeny and phylogeny

Cited by 108 publications

References 385 publications

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Role of Interstitial ATP and Adenosine in the Regulation of Renal Hemodynamics and Microvascular Function

Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems

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