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Cited by 48 publications
(43 citation statements)
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References 67 publications
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“…In fact, MTT assay measures cell viability in terms of reductive activity as enzymatic conversion of the tetrazolium compound to water insoluble formazan crystals by dehydrogenases occurring in the mitochondria of living cells [57]. This hypothesis is supported by the data of Grewal et al [58], that demonstrated the treatment with ligstroside and, at a lower extent, with 3,4-DHPEA-EDA enhanced mitochondrial respiration in SH-SY5Y-APP695 cells, a cellular model of early AD.…”
Section: Discussionmentioning
confidence: 86%
“…In fact, MTT assay measures cell viability in terms of reductive activity as enzymatic conversion of the tetrazolium compound to water insoluble formazan crystals by dehydrogenases occurring in the mitochondria of living cells [57]. This hypothesis is supported by the data of Grewal et al [58], that demonstrated the treatment with ligstroside and, at a lower extent, with 3,4-DHPEA-EDA enhanced mitochondrial respiration in SH-SY5Y-APP695 cells, a cellular model of early AD.…”
Section: Discussionmentioning
confidence: 86%
“…Results of in vitro studies showed that purified ligstroside protected against mitochondrial dysfunction by restoring ATP levels in models of early AD [70]. Female NMRI mice supplemented with oleocanthal or ligstroside (6.25 mg/kg b.w) for six months showed improved spatial working memory and ATP levels in the brain [70]. These results indicate that ligstroside can expand the lifespan in aging mice and enhance cognitive function.…”
Section: Polyphenols In Neurodegenerative Diseasesmentioning
confidence: 98%
“…Olive polyphenols are components of the Mediterranean diet. Grewal et al examined the effects of purified olive secoiridoid derivatives and their metabolites on mitochondrial function in SH-SY5Y-APP695 cells, a cellular model of early AD [70]. An aging mouse model (Female NMRI mice, aged 12 months) was used to further examine the effects of purified secoiridoids (oleocanthal and ligstroside) in vivo.…”
Section: Polyphenols In Neurodegenerative Diseasesmentioning
confidence: 99%
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“…Verbascoside, also known as acteoside or kusaginin [ 18 ], is a bio-active molecule well-known for its antioxidant, anti-inflammatory, antibacterial, antifungal, potential anticancer, and anti-tuberculosis properties [ 18 , 19 , 20 , 21 , 22 , 23 ]. In a recent study, ligstroside showed beneficial effects against Alzheimer’s disease and the capability in expanding the lifespan and enhancing the cognitive function of aged mice in vivo [ 24 ].…”
Section: Introductionmentioning
confidence: 99%