Purified black tea theaflavins and theaflavins/catechin supplements did not affect serum lipids in healthy individuals with mildly to moderately elevated cholesterol concentrations

Abstract

In this human intervention study, no statistically significant LDL-c lowering effect was seen with either TFs alone or the TFs/catechins combination as compared to placebo. Based on these findings it cannot be concluded that tea flavonoids such as theaflavins and catechins are responsible for a putative cholesterol-lowering effect of black tea, at least not with the daily dose applied in the present study.

Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials

“…Only two trials were conducted in East Asian countries [21,24] and the rest were mostly performed in America or Europe. Black tea extract capsule was used in two trials [22,24] and the remaining adopted black tea beverages as the intervention treatment. Controlled background diet was adopted only in one trial [18].…”

“…Therefore, 11 trials involved 411 adult participants were included in this metaanalysis. Six trials from 5 studies were conducted in healthy people [16,17,21,23,25] while the other five trials were performed in subjects with higher cardiovascular risk such as prediabetes or hypercholesterolemia [18e20, 22,24]. The sample size ranged from 15 to 77 with a median of 31.…”

“…using statistical software) to generate random sequence [16,19,22]. Double-blind design was employed only in two studies [18,24]. The statement and description of dropouts were reported in all of the included studies.…”

“…The sample size ranged from 15 to 77 with a median of 31. Six trials lasted for 4 weeks [17,19e21,23,25], four trials lasted longer than 10 weeks [16,22,24] and the average duration was up to 8 weeks. Only two trials were conducted in East Asian countries [21,24] and the rest were mostly performed in America or Europe.…”

“…Six trials lasted for 4 weeks [17,19e21,23,25], four trials lasted longer than 10 weeks [16,22,24] and the average duration was up to 8 weeks. Only two trials were conducted in East Asian countries [21,24] and the rest were mostly performed in America or Europe. Black tea extract capsule was used in two trials [22,24] and the remaining adopted black tea beverages as the intervention treatment.…”