Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.12.003 View full text
Kangyi Zhang, Xingguo Wang, Jianhua Huang, Yuanfa Liu

Abstract: Colorless L-alpha glycerylphosphorylcholine (L-α-GPC) was obtained at 99.8% purity, 69.8% recovery, and with a specific rotation of -2.5° via a five-step procedure. L-α-GPC was first produced by phospholipase A(1) hydrolysis of soy lecithin powder. Ca(2+) and Cl(-) were then effectively removed using two successive 001×7 cation and D311 anion exchange resin column chromatography procedures. Silica gel column chromatography and decoloration with active carbon were then applied to remove remaining impurities and…

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