Pure and Acute Korsakoff Syndrome Due to a Bilateral Anterior Fornix Infarction

MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

“…However, considering the affected regions in our cases, the column of the fornix, a constituent of the Papez neuronal circuit (On-line Fig 3), seems the most likely responsible site for the amnesia. The same hypothesis has been suggested in the literature: Infarction relatively limited to the bilateral columns of the fornices on DWI has been separately reported in 4 patients with spontaneous stroke and acute onset of amnesia, [29][30][31][32] in a patient with amnesia following clipping, 33 and in another following coiling of an unruptured ACoA aneurysm.…”

MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

“…However, considering the affected regions in our cases, the column of the fornix, a constituent of the Papez neuronal circuit (On-line Fig 3), seems the most likely responsible site for the amnesia. The same hypothesis has been suggested in the literature: Infarction relatively limited to the bilateral columns of the fornices on DWI has been separately reported in 4 patients with spontaneous stroke and acute onset of amnesia, [29][30][31][32] in a patient with amnesia following clipping, 33 and in another following coiling of an unruptured ACoA aneurysm.…”

A fornix infarction causing post-operative anterograde amnesia

“…This case reveals the relationship between the anterior fornix and memory function, as well as the role of hypoperfusion brain injury in ischemic strokes. Acute fornix infarcts are rare, and previous case reports describe acute amnesia as the main presenting symptom [3][4][5][6][7][8]. Two of these cases were due to an isolated fornix infarction [3,4], while the other cases [5][6][7][8], including the one described herein, were associated with ischemia of nearby structures, including the corpus callosum and cingulate gyrus.…”

“…Acute fornix infarcts are rare, and previous case reports describe acute amnesia as the main presenting symptom [3][4][5][6][7][8]. Two of these cases were due to an isolated fornix infarction [3,4], while the other cases [5][6][7][8], including the one described herein, were associated with ischemia of nearby structures, including the corpus callosum and cingulate gyrus. Interestingly, the case of the isolated left anterior fornix injury [4] was not clinically different to the case with the isolated bilateral fornix infarction [6], suggesting that isolated fornix lesions can cause amnesia and a lack of laterality to fornix function.…”

Ischemic amnesia caused by bilateral fornix infarction: A rare entity

“…[5] Diffusion tensor tractography, though not done in our patient, is a novel study known to show any insult like edema or infarction or Wallerian degeneration occurring to the white matter tracts and is also helpful in prediction of recovery. [67] In this case, bilateral anterior fornix infarction causes acute anterograde amnesia, likely etiological association being cryptogenic in nature in view of the absence of risk factors and normal investigations except for intracranial angiogram of cerebral vessels which was not done in this patient. He was able to recollect the events after 3 months of follow-up, with no specific rehabilitative measures followed.…”

MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

“…However, considering the affected regions in our cases, the column of the fornix, a constituent of the Papez neuronal circuit (On-line Fig 3), seems the most likely responsible site for the amnesia. The same hypothesis has been suggested in the literature: Infarction relatively limited to the bilateral columns of the fornices on DWI has been separately reported in 4 patients with spontaneous stroke and acute onset of amnesia, [29][30][31][32] in a patient with amnesia following clipping, 33 and in another following coiling of an unruptured ACoA aneurysm.…”

A fornix infarction causing post-operative anterograde amnesia

“…This case reveals the relationship between the anterior fornix and memory function, as well as the role of hypoperfusion brain injury in ischemic strokes. Acute fornix infarcts are rare, and previous case reports describe acute amnesia as the main presenting symptom [3][4][5][6][7][8]. Two of these cases were due to an isolated fornix infarction [3,4], while the other cases [5][6][7][8], including the one described herein, were associated with ischemia of nearby structures, including the corpus callosum and cingulate gyrus.…”

“…Acute fornix infarcts are rare, and previous case reports describe acute amnesia as the main presenting symptom [3][4][5][6][7][8]. Two of these cases were due to an isolated fornix infarction [3,4], while the other cases [5][6][7][8], including the one described herein, were associated with ischemia of nearby structures, including the corpus callosum and cingulate gyrus. Interestingly, the case of the isolated left anterior fornix injury [4] was not clinically different to the case with the isolated bilateral fornix infarction [6], suggesting that isolated fornix lesions can cause amnesia and a lack of laterality to fornix function.…”

Ischemic amnesia caused by bilateral fornix infarction: A rare entity

“…[5] Diffusion tensor tractography, though not done in our patient, is a novel study known to show any insult like edema or infarction or Wallerian degeneration occurring to the white matter tracts and is also helpful in prediction of recovery. [67] In this case, bilateral anterior fornix infarction causes acute anterograde amnesia, likely etiological association being cryptogenic in nature in view of the absence of risk factors and normal investigations except for intracranial angiogram of cerebral vessels which was not done in this patient. He was able to recollect the events after 3 months of follow-up, with no specific rehabilitative measures followed.…”

MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

“…However, considering the affected regions in our cases, the column of the fornix, a constituent of the Papez neuronal circuit (On-line Fig 3), seems the most likely responsible site for the amnesia. The same hypothesis has been suggested in the literature: Infarction relatively limited to the bilateral columns of the fornices on DWI has been separately reported in 4 patients with spontaneous stroke and acute onset of amnesia, [29][30][31][32] in a patient with amnesia following clipping, 33 and in another following coiling of an unruptured ACoA aneurysm.…”

A fornix infarction causing post-operative anterograde amnesia

“…This case reveals the relationship between the anterior fornix and memory function, as well as the role of hypoperfusion brain injury in ischemic strokes. Acute fornix infarcts are rare, and previous case reports describe acute amnesia as the main presenting symptom [3][4][5][6][7][8]. Two of these cases were due to an isolated fornix infarction [3,4], while the other cases [5][6][7][8], including the one described herein, were associated with ischemia of nearby structures, including the corpus callosum and cingulate gyrus.…”

“…Acute fornix infarcts are rare, and previous case reports describe acute amnesia as the main presenting symptom [3][4][5][6][7][8]. Two of these cases were due to an isolated fornix infarction [3,4], while the other cases [5][6][7][8], including the one described herein, were associated with ischemia of nearby structures, including the corpus callosum and cingulate gyrus. Interestingly, the case of the isolated left anterior fornix injury [4] was not clinically different to the case with the isolated bilateral fornix infarction [6], suggesting that isolated fornix lesions can cause amnesia and a lack of laterality to fornix function.…”

Ischemic amnesia caused by bilateral fornix infarction: A rare entity

“…[5] Diffusion tensor tractography, though not done in our patient, is a novel study known to show any insult like edema or infarction or Wallerian degeneration occurring to the white matter tracts and is also helpful in prediction of recovery. [67] In this case, bilateral anterior fornix infarction causes acute anterograde amnesia, likely etiological association being cryptogenic in nature in view of the absence of risk factors and normal investigations except for intracranial angiogram of cerebral vessels which was not done in this patient. He was able to recollect the events after 3 months of follow-up, with no specific rehabilitative measures followed.…”