Puncture of the Cisterna Magna

The rise and fall of Queckenstedt's test between 1916 and 1970, a milestone in spinal cord diagnostics and why it matters

“…The dissemination of this discovery in the United States was owed to James B. Ayer (1882–1963). He contributed significantly to the development of cisternal puncture [ 8 ] and combined it with parallel lumbar pressure measurements in patients with suspected spinal cord tumor in 1922 [ 9 ]. As a proof of concept of Queckenstedt's test, he demonstrated, through parallel measurements in 65 patients with spinal cord tumor, that cisternal CSF pressure would rise, whereas lumbar CSF pressure would not.…”

The rise and fall of Queckenstedt's test between 1916 and 1970, a milestone in spinal cord diagnostics and why it matters

“…The dissemination of this discovery in the United States was owed to James B. Ayer (1882–1963). He contributed significantly to the development of cisternal puncture [ 8 ] and combined it with parallel lumbar pressure measurements in patients with suspected spinal cord tumor in 1922 [ 9 ]. As a proof of concept of Queckenstedt's test, he demonstrated, through parallel measurements in 65 patients with spinal cord tumor, that cisternal CSF pressure would rise, whereas lumbar CSF pressure would not.…”

Cerebrospinal Fluid Pressure Dynamics as a Bedside Test in Traumatic Spinal Cord Injury to Assess Surgical Spinal Cord Decompression: Safety, Feasibility, and Proof-of-Concept

“… 15 Simultaneous cisternal and LP provided strong evidence in favor of the disconnected CSF compartments theory, since patients with spinal canal narrowing had an increase of cisternal CSFP, but a diminished response in lumbar CSFP. 15 , 29 Notably, also pachy-arachnoiditis with adhesions and infectious cord swelling may result in disturbed CSFP dynamics. Except for patient ID3 and 4, none of the patients had clinical signs of inflammation of the arachnoid mater and subarachnoid space.…”

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice

“…In humans, the CM is an established route used for CSF collection and drug injection into the central nervous system (CNS) ( Ayer, 1920 ; Lutters and Koehler, 2020 ). Recently, it has been proposed as an efficient route for CNS gene therapy in non-human primates ( Hinderer et al, 2014 ).…”

The rise and fall of Queckenstedt's test between 1916 and 1970, a milestone in spinal cord diagnostics and why it matters

“…The dissemination of this discovery in the United States was owed to James B. Ayer (1882–1963). He contributed significantly to the development of cisternal puncture [ 8 ] and combined it with parallel lumbar pressure measurements in patients with suspected spinal cord tumor in 1922 [ 9 ]. As a proof of concept of Queckenstedt's test, he demonstrated, through parallel measurements in 65 patients with spinal cord tumor, that cisternal CSF pressure would rise, whereas lumbar CSF pressure would not.…”

Cerebrospinal Fluid Pressure Dynamics as a Bedside Test in Traumatic Spinal Cord Injury to Assess Surgical Spinal Cord Decompression: Safety, Feasibility, and Proof-of-Concept

“… 15 Simultaneous cisternal and LP provided strong evidence in favor of the disconnected CSF compartments theory, since patients with spinal canal narrowing had an increase of cisternal CSFP, but a diminished response in lumbar CSFP. 15 , 29 Notably, also pachy-arachnoiditis with adhesions and infectious cord swelling may result in disturbed CSFP dynamics. Except for patient ID3 and 4, none of the patients had clinical signs of inflammation of the arachnoid mater and subarachnoid space.…”

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice

“…In humans, the CM is an established route used for CSF collection and drug injection into the central nervous system (CNS) ( Ayer, 1920 ; Lutters and Koehler, 2020 ). Recently, it has been proposed as an efficient route for CNS gene therapy in non-human primates ( Hinderer et al, 2014 ).…”

The rise and fall of Queckenstedt's test between 1916 and 1970, a milestone in spinal cord diagnostics and why it matters

“…The dissemination of this discovery in the United States was owed to James B. Ayer (1882–1963). He contributed significantly to the development of cisternal puncture [ 8 ] and combined it with parallel lumbar pressure measurements in patients with suspected spinal cord tumor in 1922 [ 9 ]. As a proof of concept of Queckenstedt's test, he demonstrated, through parallel measurements in 65 patients with spinal cord tumor, that cisternal CSF pressure would rise, whereas lumbar CSF pressure would not.…”

Cerebrospinal Fluid Pressure Dynamics as a Bedside Test in Traumatic Spinal Cord Injury to Assess Surgical Spinal Cord Decompression: Safety, Feasibility, and Proof-of-Concept

“… 15 Simultaneous cisternal and LP provided strong evidence in favor of the disconnected CSF compartments theory, since patients with spinal canal narrowing had an increase of cisternal CSFP, but a diminished response in lumbar CSFP. 15 , 29 Notably, also pachy-arachnoiditis with adhesions and infectious cord swelling may result in disturbed CSFP dynamics. Except for patient ID3 and 4, none of the patients had clinical signs of inflammation of the arachnoid mater and subarachnoid space.…”

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice

“…In humans, the CM is an established route used for CSF collection and drug injection into the central nervous system (CNS) ( Ayer, 1920 ; Lutters and Koehler, 2020 ). Recently, it has been proposed as an efficient route for CNS gene therapy in non-human primates ( Hinderer et al, 2014 ).…”