Campaigns against risk factors for non-communicable diseases (NCDs) caused by smoking and obesity have become increasingly common on multiple levels of government, from the local to the international. Nongovernmental actors have cooperated with government bodies to make policies. By analyzing the policies of the World Trade Organization, World Health Organization, European Union, and United Kingdom and United States governments, we identify how the struggles between public health advocates and commercial interests reached the global level, and how the relatively successful fight to 'denormalize' tobacco consumption has become a model for anti-obesity advocates. It highlights three factors important in policy change: framing the policy problem, the policymaking environment, and 'windows of opportunity' -to analyse the struggle between 'harm regulation' and 'neoprohibition' approaches to an international obesity prevention regime.Nutrition has become a recognized policy problem globally over the past few decades, primarily with reference to obesity, but also excessive salt consumption. In the UK, the British Medical Association [3] connects poor diet to 41% of all deaths from cardiovascular disease, and Steel et al [4] attribute over 40% of 'years of life lost' to foodrelated causes, including poor diet and high blood pressure, cholesterol, and blood glucose levels. Questions about the relationship between nutrition and health, especially calorie-