Optical-Thermal Response of Laser-Irradiated Tissue 2010 # Pulsed Laser Ablation of Soft Biological Tissues

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2024

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(20 citation statements)

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“…The complete energy deposition is required until ablation is initiated. The blow‐off model predicts the etch depth according to [22] $$\delta =\frac{1}{{\mu}_{a}}\mathit{ln}true(\frac{{H}_{0}}{{H}_{\mathrm{italicth}}}true)=\frac{1}{{\mu}_{a}}\mathit{ln}true(\frac{{I}_{0}\tau}{{H}_{\mathrm{italicth}}}true),$$ where μ a is the absorption coefficient, H 0 = I 0 τ is the radiant exposure, I 0 is the irradiance, τ is the pulse duration, and H th is the threshold of ablation. The ablation threshold is defined as the minimum radiant exposure required for tissue ablation to occur [23].…”

confidence: 99%

“…The complete energy deposition is required until ablation is initiated. The blow‐off model predicts the etch depth according to [22] $$\delta =\frac{1}{{\mu}_{a}}\mathit{ln}true(\frac{{H}_{0}}{{H}_{\mathrm{italicth}}}true)=\frac{1}{{\mu}_{a}}\mathit{ln}true(\frac{{I}_{0}\tau}{{H}_{\mathrm{italicth}}}true),$$ where μ a is the absorption coefficient, H 0 = I 0 τ is the radiant exposure, I 0 is the irradiance, τ is the pulse duration, and H th is the threshold of ablation. The ablation threshold is defined as the minimum radiant exposure required for tissue ablation to occur [23].…”

confidence: 99%

“…However, the steady‐state model assumes that heat diffusion occurs during irradiation and that tissue removal occurs at the beginning of the laser pulse, which continues during the whole irradiation. The steady‐state model anticipates an etch depth as follows [22]: $$\delta =\frac{{H}_{0}{-H}_{\mathrm{italicth}}}{{\mu}_{a}{H}_{\mathrm{italicth}}}=\frac{{I}_{0}{\tau -H}_{\mathrm{italicth}}}{{\mu}_{a}{H}_{\mathrm{italicth}}}\mathrm{.}$$ …”

confidence: 99%

“…The high efficiency makes it possible to perform intracellular and intratissue surgery, dissection and optical knock-out of cells [16][17][18][19][20][21] as well as targeted transfection by transient opening of the cellular membrane [22,23] using very low mean laser powers. This ensures to avoid collateral damage in the microenvironment due to photodisruptive effects based on the formation of bubbles and shock waves [24,25]. Formerly, using longer pulses mean powers of about 100 mW (~1 nJ) were required to induce transient holes [26][27][28].…”

confidence: 99%

“…While testing the described experimental setup directly on a real world sample might seem hasty at rst, it has to be considered that the basic mechanisms of LAESI have already been explored and published in greater detail. 1,2,[17][18][19] The methodology to be validated was in fact not the LAESI concept but focusing a laser onto an undisturbed surface of a biological sample. By demonstrating consistent laser focus on a real world sample while detecting the mass features expected to be found in said sample validated the feasibility of the experimental setup.…”

confidence: 99%