Pulsed-Dye Laser Treatment of Nonhealing Chronic Ulcer With Hypergranulation Tissue

Wang, Steven Q.; Goldberg, Leonard Harry

doi:10.1001/archderm.143.6.700

Cited by 10 publications

(8 citation statements)

References 9 publications

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“…However, the use of PDL has been described to treat post-surgical ulcers with excessive granulation tissue and the authors hypothesize that the great response is because PDL acts on the pathological angiogenesis developed on the hypergranulation tissue. 14 Finally, CO 2 laser vaporization of raspberry-like papillomas represents an effective and easily reproducible treatment, with low F I G U R E 1 Patient 1; A) erythematous atrophic lesions with relevant telangiectasias and apparent fatty herniations, B) whitening of erythematous atrophic lesions, C) hyperpigmented macules developed on top of hypopigmented areas, D) hyperpigmented macules after PDL treatment, E) raspberry-like papilloma on the upper lip before treatment, F) raspberry-like papilloma on the upper lip after treatment with CO2 laser F I G U R E 2 Patient 2; A) erosive areas with prominent granulation tissue before treatment, B) almost complete healing of previous erosive areas with prominent granulation tissue after four sessions of PDL morbidity and postoperative complication rates. The procedure is well tolerated resulting in a short postoperative period without relevant complications and can be carried out in a short period of time and allows simultaneous actuation on multiple locations.…”

Section: Discussionmentioning

confidence: 99%

Novel uses of laser therapy in Goltz syndrome

Campayo

Rego-Campuzano

Pozo

et al. 2022

Dermatologic Therapy

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Goltz syndrome is an X-linked dominant, multisystem birth defect due to PORCN mutation. The skin findings follow Blaschko's lines and often show epidermal atrophy and herniation of subcutaneous fatty tissue. Regarding treatment, light sources can offer a good therapeutic option for some manifestations of this rare disease and improve the aesthetic appearance of the skin lesions. We report two new cases of Goltz syndrome in which the cutaneous findings remarkably improved with pulsed dye laser and carbon dioxide laser.

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Section: Discussionmentioning

confidence: 99%

Novel uses of laser therapy in Goltz syndrome

Campayo

Rego-Campuzano

Pozo

et al. 2022

Dermatologic Therapy

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“…Although KTP has not been used previously for this purpose, pulsed dye laser (PDL) therapy has been used. In a small case series by Wang and Goldberg, two initial and nine total patients with nonhealing chronic ulcers and hypergranulation tissue from Mohs surgery of the face and scalp were successfully treated with 595‐nm PDL therapy plus biweekly 0.05% fluocinonide ointment and wound care 1,4 . In this group, too, the small vessels in the excessive granulation tissue were targeted to diminish proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…In this group, too, the small vessels in the excessive granulation tissue were targeted to diminish proliferation. The 595‐nm PDL laser in this capacity functioned to reduce the number of these vessels and restore the normal wound healing pattern to the tissue 1 . Laser therapy for these patients resulted in full and prompt clearance and reepithelialization.…”

Section: Discussionmentioning

confidence: 99%

“…In a small case series by Wang and Goldberg, two initial and nine total patients with nonhealing chronic ulcers and hypergranulation tissue from Mohs surgery of the face and scalp were successfully treated with 595-nm PDL therapy plus biweekly 0.05% fluocinonide ointment and wound care. 1,4 In this group, too, the small vessels in the excessive granulation tissue were targeted to diminish proliferation. The 595-nm PDL laser in this capacity functioned to reduce the number of these vessels and restore the normal wound healing pattern to the tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of the development of excessive granulation tissue is incompletely understood; predisposing factors may include healing by second intention, 1 excessive moisture, and trauma to or friction on the wound surface 2 . Treatment of this type of nonhealing wound may prove especially difficult because of the unique pathogenesis that underlies its development.…”

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Potassium Titanyl Phosphate 532-nm Laser for Treatment of a Chronic Nonhealing Exophytic Wound with Hypergranulation Tissue

Madden

Paghdal

Cohen

2011

Dermatologic Surgery

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Intra-Arterial Intervention Chemotherapy for Sarcoma and Cancerous Ulcer Via an Implanted Pump

Liu

Qiu

Guo

et al. 2014

Pathol. Oncol. Res.

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To observe the efficacy of intra-arterial chemotherapy with subcutaneously implanted pump for soft tissue sarcoma in extremities and cancerous ulcer. 31 patients with ulcerative skin squamous cell carcinoma or sarcoma in extremities who received treatment during the period from July 2003 to November 2011 at our hospital were recruited, including 15 male and 16 female patients, aging between 14 and 83 with average age of 49 years old. 10 patients had tumor in upper extremities and 21 patients in lower extremities. The pathological types of studied cases include 9 cases with skin squamous cell carcinoma, 6 cases with synovial sarcoma, 5 cases with malignant fibrous histiocytoma, 3 cases with liposarcoma, 3 cases with osteosarcoma, 2 cases with malignant melanoma, 2 cases with epidermoid sarcoma, and 1 case with protuberans. The main symptoms of cancerous ulcer were pain, infection and hemorrhage; All the studied patients were administrated with cisplatin and doxorubicin by intra-arterial chemotherapy pump, and the patients with squamous cell carcinoma were additionally applied with bleomycin and patients with malignant melanoma were additionally applied with dacarbazine. The chemotherapy efficiency was observed after at 3 cycles of intra-arterial chemotherapy. The total remission rate of pain (RR) was 87 %, and total remission rate of ulcer cicatrization (RR) was 71 %, with ulcer cicatrizing spontaneously in 9 cases and obvious homeostasis in 5 cases with bleeding ulcers. 19 patients underwent surgery after chemotherapy, in which 16 cases had limb-salvage surgery and 3 cases underwent lower leg amputation after chemotherapy, and 3 patients out of 16 cases had local recurrence (19 %). The subcutaneous intra-arterial targeting chemotherapy could be applied to treat refractory sarcoma and cancerous ulcer in extremities to significantly increase the chemotherapeutic concentration at tumor area so as to effectively constrain the tumor rupture induced main symptoms including pain, infection and bleeding, which would help to make a decreased blood supplied and well defined tumor boundary to finally decrease the recurrence rate.

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Pulsed-Dye Laser Treatment of Nonhealing Chronic Ulcer With Hypergranulation Tissue

Cited by 10 publications

References 9 publications

Novel uses of laser therapy in Goltz syndrome

Novel uses of laser therapy in Goltz syndrome

Potassium Titanyl Phosphate 532-nm Laser for Treatment of a Chronic Nonhealing Exophytic Wound with Hypergranulation Tissue

Intra-Arterial Intervention Chemotherapy for Sarcoma and Cancerous Ulcer Via an Implanted Pump

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