Pulsed carbon dioxide laser, trichloroacetic acid, Baker-Gordon phenol, and dermabrasion: a comparative clinical and histologic study of cutaneous resurfacing in a porcine model

Fitzpatrick, Richard

doi:10.1001/archderm.132.4.469

Cited by 36 publications

(1 citation statement)

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“…Among them, the clinical grading system is more widely used because it is the easiest way to perform and therefore more practical in the clinical setting. The variety of scoring and scaling systems for assessing facial wrinkles can be classified as descriptive grading scales [ 3 5 ] , photographic grading scales [ 6 14 ] and visual analog scales [ 4 ] . However, there is no "gold standard" among grading scales and almost all of the scales mentioned above are based on Caucasian individuals.…”

Section: Introductionmentioning

confidence: 99%

Classification of facial wrinkles among Chinese women

et al. 2017

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It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 Chinese women. Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected, including grading scales for resting and hyperkinetic crow's feet, frontalis lines, glabellar frown lines, and nasolabial folds. To identify the scale by objective quantitative measurement, skin surface measurements from the Visioscan® VC98 were used. To test the reliability and validity of our wrinkle scale, a multi-rater consensus method was used. A double-blind, randomized, vehicle-controlled 12-week study was conducted to use this clinical photo-score to evaluate the efficacy and safety of Centella triterpenes cream® in treating crow's feet. A newly developed 10-point photographic and descriptive scale emerged from this study. The final atlas of these photographs contained a total of 6 sets with 10 pictures each. From 0 to 9, surface evaluation of smoothness (SEsm) parametric measurements decreased progressively, indicating that the scale increased inversely. Weighted kappa coefficients for intra-assessor were between 0.75-0.87. The overall Kendall's coefficient is 0.86 on the first rating and 0.87 on the second rating. Thirty-six volunteers were recruited and 35 subjects completed a 12-week trial. Clinical photo-score by investigator showed a significant difference (P<0.05) between the treatment side and control side after 4 weeks. Use of these scales in clinical settings to evaluate facial wrinkles in Asians individuals is recommended.

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Section: Introductionmentioning

confidence: 99%

Classification of facial wrinkles among Chinese women

et al. 2017

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The Validity of Ex Vivo Laser Skin Treatment for Histological Analysis

Greene

Egbert²,

Utley³

et al. 1999

Archives of Facial Plastic Surgery

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Background: Laser treatment of skin following removal from human subjects has been the staple of laser research. However, no study has been done to assess the efficacy of ex vivo skin for predicting the behavior of laser treatments in living human tissue.Objective: To assess the validity of the ex vivo model by comparing histological characteristics of skin treated with laser prior to and following its removal in rhytidectomy.Study Design: Nonrandomized controlled intervention study in which each patient served as both experimental subject and control for different skin sites.Patients: Ten patients with actinic skin changes.Interventions: Patients underwent laser treatment to 4 left preauricular sites 1 hour prior to rhytidectomy as follows: carbon dioxide laser treatment alone, carbon dioxide laser treatment followed by erbium:YAG laser treatment, erbium:YAG laser treatment alone, and erbium: YAG laser treatment followed by carbon dioxide laser treatment. The skin was examined by a dermatopathologist blinded to the identity of each specimen. Untreated skin was also removed and immediately subjected to laser treatment identical to that employed in the in vivo skin. This skin was examined histologically.Main Outcome Measures: Regularity of ablation, depth of the necrotic zone, amount of skin removed, degree of collagen injury, and degree of inflammation.

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