1997
DOI: 10.1001/archderm.133.2.229
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Pulse intravenous cyclophosphamide for treatment of autoimmune blistering disease. Is there an advantage over oral routes?

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Cited by 6 publications
(12 citation statements)
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“…18 The rates of premature infertility are high for both oral and pulsed cyclophosphamide with approximately 50% of patients on pulsed therapy developing this often irreversible complication. 5 Our study reports a 27% (3 of 11) incidence of premature infertility in female patients, which, although lower than previous reports, is still a significant risk. We believe that PPC is inappropriate for women of child-bearing age due to the risk of ovarian failure and in male patients semen banking should be considered as azoospermia is a potential complication of cyclophosphamide.…”
Section: Discussioncontrasting
confidence: 64%
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“…18 The rates of premature infertility are high for both oral and pulsed cyclophosphamide with approximately 50% of patients on pulsed therapy developing this often irreversible complication. 5 Our study reports a 27% (3 of 11) incidence of premature infertility in female patients, which, although lower than previous reports, is still a significant risk. We believe that PPC is inappropriate for women of child-bearing age due to the risk of ovarian failure and in male patients semen banking should be considered as azoospermia is a potential complication of cyclophosphamide.…”
Section: Discussioncontrasting
confidence: 64%
“…It suppresses the number and function of B and T lymphocytes with particular activity against B cells and as a result reduces antibody production. 4 A considerable body of evidence 5,6 suggests that its toxicity is reduced when it is administered intravenously in monthly pulses. Its use is established in a number of autoimmune diseases including lupus nephritis and Wegener's granulomatosis as well as dermatological conditions including autoimmune, neoplastic, granulomatous and neutrophilic disorders.…”
Section: Discussionmentioning
confidence: 99%
“…There are two CYC administration routes -oral and intravenous pulses; both have been used to treat patients with MMP. 1,[6][7][8][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Most studies investigating the effect of CYC in the treatment of MMP concentrated on ocular MMP, and CYC treatment was usually combined with systemic corticosteroids; hardly ever was the time period from the first CYC administration to clinical improvement mentioned. The results of Foster's study, which investigated CYC efficacy without corticosteroid adjunction, showed a good efficacy in ocular inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…monthly pulses, compared with the previously used daily oral regimens. 3,5 This article reviews the literature on cyclophosphamide and its applications in dermatology.…”
Section: Introductionmentioning
confidence: 99%