2017
DOI: 10.1186/s13287-017-0506-5
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Abstract: BackgroundExperiments have previously demonstrated the therapeutic potential of mobilized dental pulp stem cells (MDPSCs) for complete pulp regeneration. The aim of the present pilot clinical study is to assess the safety, potential efficacy, and feasibility of autologous transplantation of MDPSCs in pulpectomized teeth.MethodsFive patients with irreversible pulpitis were enrolled and monitored for up to 24 weeks following MDPSC transplantation. The MDPSCs were isolated from discarded teeth and expanded based … Show more

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Cited by 287 publications
(259 citation statements)
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“…Although the cell‐based approach of regenerative endodontics has been initiated clinically in immature permanent teeth with irreversible pulpitis (Nakashima et al . ), the microenvironment in the canal space and status of Hertwig's epithelial root sheath and apical papilla in immature permanent teeth with irreversible pulpitis is quite different from those in immature permanent teeth with infected necrotic pulps.…”
Section: Resultsmentioning
confidence: 95%
See 1 more Smart Citation
“…Although the cell‐based approach of regenerative endodontics has been initiated clinically in immature permanent teeth with irreversible pulpitis (Nakashima et al . ), the microenvironment in the canal space and status of Hertwig's epithelial root sheath and apical papilla in immature permanent teeth with irreversible pulpitis is quite different from those in immature permanent teeth with infected necrotic pulps.…”
Section: Resultsmentioning
confidence: 95%
“…Most recently, the cell‐based approach for pulp regeneration was initiated in clinical trial in teeth with irreversible pulpitis (Nakashima et al . ). Animal and human studies provide some proof of principle that pulp tissue regeneration can be achieved by the cell‐based approach.…”
Section: Cell‐based Approachmentioning
confidence: 97%
“…In addition, DPSCs transplanted with granulocyte colony‐stimulating factor in collagen for dental pulp tissues regeneration after pulpectomy had excellent regeneration capacity (Nakashima et al . ).…”
Section: Introductionmentioning
confidence: 97%
“…Although the focus of this report is GFs role within cell-homing procedures, if we extrapolate evidence from SC-based regenerative therapies, it is evident that the use of transplanted SCs and selected exogenous GFs including bFGF [104], or chemokines such as SDF-1, can regenerate pulp tissue in vitro and in vivo [105]. Although complicated by safety, expense, and ethical issues, novel research in SC-based therapies has progressed to the clinical trial stage in Japan, a trial in which a DPSC population was transplanted with the cytokine G-CSF in an atelocollagen scaffold [106, 107]. This exciting work also offers opportunities to extrapolate and consider the most effective way to optimize the combination of migrating SCs, exogenous signaling molecules/GFs, and extracellular scaffolds [108] in revitalization procedures.…”
Section: Reviewmentioning
confidence: 99%