Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs

Stenmark, Kurt R.; Krafsur, Greta M.; Tuder, Rubin M.

doi:10.1177/0300985816647454

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…In human medicine, it is believed that PVOD and PCH are multifactorial processes. These include genetic predisposition, exposure to exogenic substrates (chemical agents), infections, and immune-mediated reactions ( Stenmark et al ., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of dogs and cats with a mixed form of pulmonary hypertension and suspected pulmonary capillary hemangiomatosis in comparison to animals with predomination of precapillary pulmonary hypertension

Arkadievich

2024

Open Vet J

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Background: Pulmonary capillary hemangiomatosis (PCH) is an idiopathic disease with the anomalous proliferation of a small capillary-like vessel in the pulmonary tissue, which can lead to a severe form of PH. There are only several cases of PCH described in veterinary literature: 27 cases in dogs and 2 cases in cats. In veterinary medicine, PH is mostly recognized as a consequence of left heart failure as a progression of the postcapillary PH to the precapillary form. PCH is mostly described as a primary disease, but resistant postcapillary PH with the high possibility of pulmonary edema raises a speculation that PCH could be a secondary malformation to the left heart disease. Aim: Discover the features associated with the shift between left- and right-sided heart disease in the context of PH development Methods: Retrospective analysis of materials from cats and dogs with histological markers of PCH (sPCH) versus those with right heart failure (RHF). Results: Animals with histological and immunohistochemistry markers of PCH had previous history of disease with the left heart volume overload. There were no differences between the groups in radiography and gross pathology. Histologically, pulmonary fibrosis and arteriopathy could be found in RHF; in sPCH – a duplication of capillaries in alveolar septa and bizarre proliferation in surroundings structures. Conclusion: PCH could be a secondary pattern of vascular remodeling due to volume overload

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Section: Discussionmentioning

confidence: 99%

Retrospective analysis of dogs and cats with a mixed form of pulmonary hypertension and suspected pulmonary capillary hemangiomatosis in comparison to animals with predomination of precapillary pulmonary hypertension

Arkadievich

2024

Open Vet J

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“…Finally, an immune-mediated form of the disease is seen, especially in association with sarcoidosis, granulomatosis of Langerhans, connective tissue disease, Hashimoto's thyroiditis and, occasionally, HIV. 43,46 There are several reports of PVOD occurring in the dog, [47][48][49][50] and two reports of PCH in the cat. 51,52 PH due to left heart disease Left-sided ventricular or valvular diseases can produce elevated left atrial (LA) pressures, which, in turn, can elevate pulmonary venous pressures and result in PCH and, ultimately, PH -so-called post-capillary PH.…”

Section: Drug or Toxin Inducedmentioning

confidence: 99%

“…Finally, an immune-mediated form of the disease is seen, especially in association with sarcoidosis, granulomatosis of Langerhans, connective tissue disease, Hashimoto’s thyroiditis and, occasionally, HIV. 43,46 There are several reports of PVOD occurring in the dog, 47–50 and two reports of PCH in the cat. 51,52…”

Section: Classification Of Phmentioning

confidence: 99%

Feline pulmonary hypertension: are we overlooking an important comorbidity?

Rolph

Cavanaugh

2022

Journal of Feline Medicine and Surgery

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Pulmonary hypertension (PH) is a potential complication in many disease states, yet it has been largely overlooked in feline medicine. Recently, increased awareness of potential underlying causes has led to a wider understanding of the disease process in humans, with a focus on tailoring therapy to include specific treatment of the underlying etiology. Most of these treatments are not yet available in veterinary medicine, but as they move from the human to the veterinary field, it would be beneficial to better understand the forms of PH encountered in different species. Recently, diagnosis and classification of PH in dogs has been the focus of an American College of Veterinary Internal Medicine consensus statement, yet this condition has received little attention in cats. It is therefore our intention to raise awareness of this condition in cats and to propose a classification system for the types of PH seen in feline patients. As new medications are developed for the treatment of PH, it is important to recognize which forms of PH are seen in feline patients and understand the etiology of the disease. There are many reports of PH (or suspected PH based on echocardiographic assessment) in cats. In this review, we highlight the large number of conditions, and different etiologies, that are associated with PH. Improving understanding of this condition will bring us closer to being able to investigate the benefits of potential new diagnostics and therapies as they become available.

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“…Pulmonary veno-occlusive disease (PVOD) is a rare pathological change seen in both humans and animals. Pulmonary veno-occlusive disease occurs as a severe and uncommon variant of pulmonary hypertension (PH) which remains a miscellaneous problem (8,13,18). According to the World Health Organization (WHO), PH is generally classified by the underlying cause: pulmonary arterial hypertension (PAH), Left Heart Disease, chronic obstructive pulmonary disease, chronic pulmonary thromboembolic disease, and unclear multifactorial mechanisms (11).…”

Section: Lenfomalı Bir Kedide Pulmoner Veno-oklüzif Hastalıkmentioning

confidence: 99%

Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma

Tenekeci

Terzi

Şahal

et al. 2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Pulmonary veno-occlusive disease (PVOD) is an uncommon disease in humans and animals caused by pulmonary hypertension (PH). The aim of this study was to investigate pathomorphological findings of PVOD in a cat. A mass was detected in the right atrium with echocardiography in an 11-year-old male cat. Following treatments, necropsy of the cat was performed after death due to respiratory failure. Macroscopically, masses were detected in mesenteric lymph node, mediastinal lymph node and, heart. Congestion and consolidated areas with edema were seen in the examination of the lung. Histopathologically, neoplastic lymphoid cells were observed in intestine, lymph nodes and heart. In lung, vein lumens were almost completely occluded by mostly loose intimal fibrosis. Near affected veins, increasing in number of the capillaries was observed. While intimal fibrosis was detected by Masson's trichrome staining, the occluded veins were demonstrated by Verhoeff-van Gieson staining. In this case report, pathomorphological evaluation of PVOD was performed and as a result of clinicopathological examinations; PVOD, intestinal lymphoma, and cardiac metastasis were described in a male cat.

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Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs

Cited by 6 publications

References 24 publications

Retrospective analysis of dogs and cats with a mixed form of pulmonary hypertension and suspected pulmonary capillary hemangiomatosis in comparison to animals with predomination of precapillary pulmonary hypertension

Retrospective analysis of dogs and cats with a mixed form of pulmonary hypertension and suspected pulmonary capillary hemangiomatosis in comparison to animals with predomination of precapillary pulmonary hypertension

Feline pulmonary hypertension: are we overlooking an important comorbidity?

Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma

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