Pulmonary sarcoidosis with arterial involvement

Abstract

Necrotizing sarcoid granulomatosis (NSG) is a rare and under-recognized cause of granulomatous disease, described as a variant of typical nodular sarcoidosis. It can be asymptomatic when the patient has a single pulmonary nodule or may be accompanied by cough, fever, and dyspnea, or even symptoms due to the involvement of other organs such as the eyes, liver, and central nervous system. The histopathological analysis is essential for the differential diagnosis of other infectious and non-infectious causes of granuloma and to determine the appropriate treatment. NSG is characterized by the presence of a granuloma with extensive coagulative necrosis associated with the occurrence of vasculitis. We present the case of a patient diagnosed with NSG who had an unusual outcome with recurrent pulmonary thromboembolisms followed by hemodynamic instability and death.

Necrotic sarcoid granulomatosis – a late stage of nodular sarcoidosis or an independent disease? Analysis of a clinical case

“…Помимо этого, НСГ иногда дифференцируется с ГПА, при котором васкулит может быть обнаружен в редких очагах и в некотором удалении от некротизированных масс. Наоборот, при НСГ васкулит обнаруживается в очагах некроза, в больших узелковых образованиях [27].…”