Pulmonary-renal syndrome in association with anti-GBM and IgM ANCA

Antineutrophil Cytoplasmic Antibodies of IgA Class in Neutrophilic Dermatoses With Emphasis on Erythema Elevatum Diutinum

“…When positive, they often occur in association with the more frequent IgG ANCA. 24,25 They likely represent early markers of ANCA seroconversion. The ANCAs of the IgA class may be detected in several conditions, including Henoch-Shö enlein purpura, 26 inflammatory bowel disease, 27 and cystic fibrosis, 28 but their clinical value remains unclear.…”

Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies

“…The incidence of ANCA in anti-GBM antibodyrelated disease is reported as approximately 30%-40% (4). In this case, as usual, both antibodies were present at the diagnosis (7). However, the appearance of the anti-GBM may occur both before ANCA (7) and later after kidney injury due to pauci-immune origin of crescentic glomerulonephritis (3,8), and the renal outcome is anyhow poor.…”

“…In this case, as usual, both antibodies were present at the diagnosis (7). However, the appearance of the anti-GBM may occur both before ANCA (7) and later after kidney injury due to pauci-immune origin of crescentic glomerulonephritis (3,8), and the renal outcome is anyhow poor. However, McAdoo et al (9) described a group of patients in which double-positive was associated with a better trend of renal function but burdened by high mortality.…”

Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies

“…In the first course, anti-GBM antibody titers increase after kidney injury secondary to pauciimmune crescentic glomerulonephritis [6][7][8]. In the second course, ANCA becomes positive after the development of anti-GBM antibody-related glomerulonephritis [9][10][11]. The most common course is the third course, in which both antibodies are detected at the diagnosis of RPGN.…”