Pulmonary Paracoccidioidomycosis

Calich, Vera Lúcia Garcia; Blotta, Maria Heloı́sa Souza Lima

doi:10.1007/0-387-25445-5_10

Cited by 22 publications

(36 citation statements)

References 98 publications

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“…Indeed, immunoprotection to PCM is typically associated with the production of type 1 cytokines (IL-12, IFN-␥) and disease exacerbation with type 2 or anti-inflammatory cytokines [5,40]. Although unusual, our result explains some previous findings that characterize the genetic model of resistance and susceptibility to P. brasiliensis infection.…”

Section: Discussionsupporting

confidence: 68%

“…Thus, despite the deactivated behavior in innate immunity, AM of A/J mice could develop into efficient APC and induce T cell immunity. In agreement, resistant mice were shown to mount a balanced Th1/Th2 CD4 ϩ T cell immunity besides a protective, type 1, CD8 ϩ T cell response [5,6,13,47]. Consistent with these findings, a recent work showed that dendritic cells from resistant mice induce a better activation of naïve T cells than those from susceptible mice [48].…”

Section: Discussionsupporting

confidence: 67%

“…The results here presented appear to explain this unusual behavior and demonstrate that susceptibility to P. brasiliensis infection is associated with an efficient innate immune response. Indeed, other results from our laboratory confirmed such behavior: B10.A mice secrete increased levels of leukotrienes, and this lipid mediator is used to increase the rate of P. brasiliensis phagocytosis and increased fungal loads, despite the high macrophage activation [5,28,41]. In the same line, Toll-like receptors 2 and 4 were shown to be used by P. brasiliensis yeasts to gain entry into macrophages and to activate macrophages which, however, do not control fungal multiplication [42].…”

Section: Discussionsupporting

confidence: 62%

“…Trying to reconcile results here reported for innate immunity with the major features of the adaptative immunity described previously for our model [5,13,47], we further studied the expression of some costimulatory molecules on P. brasiliensisinfected AM. As can be seen in Fig.…”

Section: Discussionmentioning

confidence: 76%

“…The most common form of PCM, the adult form, has a chronic evolution and preferentially affects male individuals. The chronic mild cases are more frequently associated with a Th1-skewed pattern of immunity, whereas a more prominent Th2 profile in observed in the most severe cases [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initialParacoccidioides brasiliensisinfection

Pina

Bernardino²,

Calich³

2008

Journal of Leukocyte Biology

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Unexpectedly, our results demonstrated that susceptibility to a fungal pathogen can be associated with an efficient innate immunity, while a deficient innate response can ultimately favor the development of a resistant pattern to infection. Moreover, our data suggest that different pathogen recognition receptors are used by resistant and susceptible hosts to interact with P. brasiliensis yeasts, resulting in divergent antigen presentation, acquired immunity, and disease outcomes.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionsupporting

confidence: 67%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initialParacoccidioides brasiliensisinfection

Pina

Bernardino²,

Calich³

2008

Journal of Leukocyte Biology

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Innate immunity to Paracoccidioides brasiliensis infection

et al. 2008

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Innate immunity is based in pre-existing elements of the immune system that directly interact with all types of microbes leading to their destruction or growth inhibition. Several elements of this early defense mechanism act in concert to control initial pathogen growth and have profound effect on the adaptative immune response that further develops. Although most studies in paracoccidioidomycosis have been dedicated to understand cellular and humoral immune responses, innate immunity remains poorly defined. Hence, the main purpose of this review is to present and discuss some mechanisms of innate immunity developed by resistant and susceptible mice to Paracoccidioides brasiliensis infection, trying to understand how this initial host-pathogen interface interferes with the protective or deleterious adaptative immune response that will dictate disease outcome. An analysis of some mechanisms and mediators of innate immunity such as the activation of complement proteins, the microbicidal activity of natural killer cells and phagocytes, the production of inflammatory eicosanoids, cytokines, and chemokines among others, is presented trying to show the important role played by innate immunity in the host response to P. brasiliensis infection.

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Influence of pH on the Molecular Weight of Poly-3-hydroxybutyric Acid (P3HB) Produced by Recombinant Escherichia coli

Bocanegra

Pradella²,

Silva

et al. 2013

Appl Biochem Biotechnol

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The production of ultrahigh molecular weight poly-3-hydroxybutyric acid (P3HB) from carbohydrates by recombinant Escherichia coli harboring genes from Ralstonia eutropha was evaluated. In shaken-flask experiments, E. coli XL1 Blue harboring plasmid pSK::phaCAB produced P3HB corresponding to 40 and 27% of cell dry weight from glucose and xylose, respectively. Cultures in bioreactor using glucose as the sole carbon source at variable pH values (6.0, 6.5, or 7.0) allowed the production of P3HB with molecular weight varying between 2.0 and 2.5 MDa. These figures are significantly higher than the values often obtained by natural bacterial strains (0.5-1.0 MDa). Contrary to reports of other authors, no influence of pH was observed on the molecular weight of the polymer produced. Using xylose, P3HB with high molecular weight was also produced, indicating the possibility to produce these polymers from lignocellulosic materials.

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Pulmonary Paracoccidioidomycosis

Cited by 22 publications

References 98 publications

Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initialParacoccidioides brasiliensisinfection

Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initialParacoccidioides brasiliensisinfection

Innate immunity to Paracoccidioides brasiliensis infection

Influence of pH on the Molecular Weight of Poly-3-hydroxybutyric Acid (P3HB) Produced by Recombinant Escherichia coli

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