Pulmonary nodules: differential diagnosis using 18F-fluorodeoxyglucose single-photon emission computed tomography.

Worsley, Dan; Celler, Anna; Adam, Michael J.; Kwong, Justin; Müller, Néstor L.; Coupland, David B.; Champion, P; Finley, Richard J.; Evans, Ken; Lyster, Donald M.

doi:10.2214/ajr.168.3.9057532

Cited by 29 publications

(5 citation statements)

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“…Thus angiogenesis in malignant tumors plays an important role in the enhancement of malignant tumors. Less contrast medium is delivered to hypovascular benign SPNs than to hypervascular In radiopathologic, pharmacokinetic, and pathologic studies [4-11, [19][20][21][22][23][24], increased blood flow, perfusion, and capillary permeability have been observed not only in malignant neoplasms but also in tissues with active inflammation, although the pathophysiologic mechanisms and theories of these two diseases may be different. The pharmacokinetics of contrast medium can be approximated to a two-compartment model with intravascular and extravascular compartments [25].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Investigation of Solitary Pulmonary Nodules: Dynamic Contrast-Enhanced MRI and Histopathologic Analysis

Zou

Zhang

Wang

et al. 2008

American Journal of Roentgenology

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Section: Discussionmentioning

confidence: 99%

Quantitative Investigation of Solitary Pulmonary Nodules: Dynamic Contrast-Enhanced MRI and Histopathologic Analysis

Zou

Zhang

Wang

et al. 2008

American Journal of Roentgenology

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“…Since the early 1990s, this hypothesis has been applied to CT, magnetic resonance (MR) imaging, positron emission tomography (PET), and more recently single photon emission computed tomography (SPECT) (4).…”

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confidence: 99%

Solitary Pulmonary Nodules: Meta-analytic Comparison of Cross-sectional Imaging Modalities for Diagnosis of Malignancy

Cronin¹,

Dwamena²,

Kelly³

et al. 2008

Radiology

205

114

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“…However, published data on cardiac FDG studies reported results comparable to dedicated PET (18). The value of such devices in oncological patients is seen as controversial since most malignant lesions smaller than 2-3 cm were not detected with FDG SPET (7,13,17,19,28,29). A more recent approach are modified dual head gamma cameras capable of single photon imaging as well as of coincidence detection of positron emitters like FDG.…”

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confidence: 99%

F-18-FDG Positron Imaging in Oncological Patients: Gamma Camera Coincidence Detection versus Dedicated PET

Zimny¹,

Kaiser²,

Cremerius³

et al. 1999

Nuklearmedizin

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Summary Aim of the present study was to investigate the feasibility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) imaging in oncological patients with a dual head gamma camera modified for coincidence detection (MCD). Methods: Phantom studies were done to determine lesion detection at various lesion-to-background ratios, system sensitivity and spatial resolution. Thirty-two patients with suspected or known malignant disease were first studied with a dedicated full-ring PET system (DPET) applying measured attenuation correction and subsequently with an MCD system without attenuation correction. MCD images were first interpreted without knowledge of the DPET findings. In a second reading, MCD and DPET were evaluated simultaneously. Results: The phantom studies revealed a comparable spatial resolution for DPET and MCD (5.9 × 6.3 × 4.2 mm vs. 5.9 × 6.5 × 6.0 mm). System sensitivity of MCD was less compared to DPET (91 cps/Bq/ml/cmF0V vs. 231 cps/ Bq/ml/cmFOv). At a lesion-to-background ratio of 4:1, DPET depicted a minimal phantom lesion of 1.0 cm in diameter, MCD a minimal lesion of 1.6 cm. With DPET, a total of 91 lesions in 27 patients were classified as malignant. MCD without knowledge of DPET results revealed increased FDG uptake in all patients with positive DPET findings. MCD detected 72 out of 91 DPET lesions (79.1 %). With knowledge of the DPET findings, 11 additional lesions were detected (+12%). MCD missed lesions in six patients with relevance for staging in two patients. All lesions with a diameter above 18 mm were detected. Conclusion: MCD FDG imaging yielded results comparable to dedicated PET in most patients. However, a considerable number of small lesions clearly detectable with DPET were not detected by MCD alone. Therefore, MCD cannot yet replace dedicated PET in all oncological FDG studies. Further technical refinement of this new method is needed to improve image quality (e.g. attenuation correction).

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Pulmonary nodules: differential diagnosis using 18F-fluorodeoxyglucose single-photon emission computed tomography.

Cited by 29 publications

References 0 publications

Quantitative Investigation of Solitary Pulmonary Nodules: Dynamic Contrast-Enhanced MRI and Histopathologic Analysis

Quantitative Investigation of Solitary Pulmonary Nodules: Dynamic Contrast-Enhanced MRI and Histopathologic Analysis

Solitary Pulmonary Nodules: Meta-analytic Comparison of Cross-sectional Imaging Modalities for Diagnosis of Malignancy

F-18-FDG Positron Imaging in Oncological Patients: Gamma Camera Coincidence Detection versus Dedicated PET

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