Pulmonary neuroendocrine tumor in a female wolf (&lt;i&gt;Canis lupus lupus&lt;/i&gt;)

Shiraki, Ayako; Yoshida, Toshinori; Kawashima, Masahi; Murayama, Hirotada; Nagahara, Rei; Ito, Nanao; Shibutani, Makoto

doi:10.1292/jvms.16-0490

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Besides, data on tumours in wolf are limited, and until now, a squamous cell carcinoma of the tonsil and pulmonary neuroendocrine tumour were reported (Shiraki et al., 2017 ; Teifke et al., 2005 ). In this regard, our present case represents a valuable addition to the knowledge on neoplasia in wolf.…”

Section: Figurementioning

confidence: 99%

Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus)

Yang

Yun

Lee

et al. 2022

Veterinary Medicine & Sci

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A 14-year-old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate.Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS-D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha-SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high-grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. K E Y W O R D Sgrey wolf, mucoepidermoid carcinoma, zoo animal Salivary glands are exocrine glands located in the oral cavity of vertebrates. The glands, as the name implies, produce and secrete saliva containing digesting enzymes as well as antibodies. Salivary glands are divided into major and minor salivary glands and are widely distributed over the face (Dyce et al., 2009).According to the current classification by the World Health Organization (WHO), salivary gland tumours are classified into 10 and 24 specific benign and malignant epithelial tumours in human, respectively (Nagao et al., 2012). However, in veterinary medicine, detailed classification has less importance. For treatment and prognosis evaluation, the focus is on diagnosing malignant and benign (Meuten, 2017).Malignant salivary gland tumours in domestic animals occur more frequently compared to benign tumours, and the most common types areThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Figurementioning

confidence: 99%

Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus)

Yang

Yun

Lee

et al. 2022

Veterinary Medicine & Sci

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“…The tumor cells mimiced those in the right adrenal gland, with evidence of a nest-like growth pattern with necrosis and hemorrhage. The tumor cells in both the adrenal glands and the liver were further examined by immunohistochemical analysis, as described previously [ 8 ], with the primary antibody against chromogranin A (CGA; Yanaihara Institute Inc., Shizuoka, Japan), a neuroendocrine marker for pheochromocytoma [ 3 ]. The tumor cells in both the adrenal glands and the liver did not express chromogranin A, which tested positive in the adrenal medulla (data not shown).…”

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Clinical and pathological features and outcome of bilateral incidental adrenocortical carcinomas in a dog

Nabeta

Osada

Ogawa

et al. 2017

The Journal of Veterinary Medical Science

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A 9-year-old, spayed female Chihuahua was presented with a 1-week history of lethargy and anorexia. Abdominal ultrasonography and computed tomography found bilateral adrenal masses without metastasis. Serum cortisol levels that were sampled before and after an adrenocorticotropic hormone stimulation test were within reference ranges. Lethargy and anorexia completely resolved after short-term fluid therapy; the clinical signs did not occur for approximately 8 months until her sudden death. A postmortem examination revealed bilateral adrenocortical carcinomas and liver metastasis. Primary adrenocortical carcinomas developed in the dog met the definition of bilateral incidental adrenal gland masses (IAGMs). This is the first case report to demonstrate based on histological identification that adrenocortical carcinomas cause bilateral IAGMs in dogs.

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Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (Canis lupus lupus) and a Review of the Current Literature

Rodríguez

Morandi²,

Cavicchio³

et al. 2020

Veterinary Sciences

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Neoplastic diseases are rarely described in wild carnivores; only a few reports have been published on this topic. Here, we describe the histological and immunohistochemical features of a haemangioma in the spleen of a grey wolf (Canis lupus lupus) and we compare the results with the dog (Canis lupus familiaris). Additionally, we list the different publications found in the literature with neoplastic lesions in wolves. Our results show similar immunohistochemical features to dogs, in which neoplastic cells express Vimentin, von Willebrand factor, alpha smooth muscle actin antibody, vascular endothelial growth factor C and low vascular endothelial growth factor receptor 3. Toluidine blue special stain shows moderated increased numbers of mast cells infiltrating the tumor, a feature observed in benign vascular tumors in domestic dogs, but not in the malignant counterparts. To our knowledge, this is the first article describing the gross, histological and immunohistochemical features of a splenic haemangioma in a wolf.

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Pulmonary neuroendocrine tumor in a female wolf (<i>Canis lupus lupus</i>)

Cited by 3 publications

References 12 publications

Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus)

Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus)

Clinical and pathological features and outcome of bilateral incidental adrenocortical carcinomas in a dog

Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (Canis lupus lupus) and a Review of the Current Literature

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