Pulmonary manifestations of chronic granulomatous disease

Mahdaviani, Seyed Alireza; Mohajerani, Seyed Amir; Rezaei, Nima; Casanova, Jean‐Laurent; Mansouri, Davood; Velayati, Ali Akbar

doi:10.1586/eci.12.98

Cited by 51 publications

(42 citation statements)

References 56 publications

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“…In a USA cohort, Aspergillus species were the most common isolated pathogens, in both pneumonia (41%) and lung abscesses (23%) [2]. Other less frequent infectious manifestations are pleural effusion, bronchiectasis, bronchitis, atelectasis, and mediastinal and hilar lymphadenopathy [10]. Chronic lung findings of Case 1 were related to recurrent and inadequately treated infections leading to his last admission with severe pneumothorax.…”

Section: Discussionmentioning

confidence: 99%

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Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Akarcan

Karaca

Aksu

et al. 2017

Case Reports in Immunology

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Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding gp91phox protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus. In addition to medical therapy, surgical treatment was necessary for the management of the disease. A 30-month-old girl with an autosomal recessive form of chronic granulomatous disease (CYBA gene mutation affecting p22phox protein) had invasive aspergillosis causing pericarditis, pulmonary abscess, and central nervous system involvement. The devastating course of disease regardless of the mutation emphasizes the importance of early diagnosis and intervention of hematopoietic stem cell transplantation as soon as possible in children with CGD.

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Section: Discussionmentioning

confidence: 99%

“…Inflammatory pulmonary manifestations such as granuloma formation, pneumonitis, and fibrosis may be seen in CGD patients [10]. Pulmonary granulomatous disease is diagnosed histologically with a negative culture and may be confused with mycobacterial infection [3].…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Akarcan

Karaca

Aksu

et al. 2017

Case Reports in Immunology

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“…This leads to severe recurrent infections and unexplained prolonged inflammatory reactions that may produce granulomatous lesions mainly in the lung. The pulmonologists (pediatrics or adult) need to be able to recognize different lung manifestations of CGD for a best diagnosis [22]. …”

Section: Discussionmentioning

confidence: 99%

Pediatric recurrent respiratory tract infections: when and how to explore the immune system? (About 53 cases)

El-Azami-El-Idrissi¹,

Lakhdar-Idrissi²,

Chaouki³

et al. 2016

Pan Afr Med J

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Recurrent respiratory tract infections are one of the most frequent reasons for pediatric visits and hospitalization. Causes of this pathology are multiple ranging from congenital to acquired and local to general. Immune deficiencies are considered as underlying conditions predisposing to this pathology. Our work is about to determine when and how to explore the immune system when facing recurrent respiratory infections. This was based on the records of 53 children hospitalized at the pediatrics unit of Hassan II University Hospital, Fez Morocco. Thirty boys and 23 girls with age ranging from 5 months to 12 years with an average age of 2 years were involved in this study. Bronchial foreign body was the main etiology in children of 3 to 6 year old. Gastro-esophageal reflux, which in some cases is a consequence of chronic cough, as well as asthma were most frequent in infants (17 and 15% respectively). Immune deficiency was described in 7.5% of patients and the only death we deplored in our series belongs to this group. Recurrent respiratory tract infections have multiple causes. In our series they are dominated by foreign body inhalation and gastroesophageal reflux, which in some cases is a consequence of a chronic cough. Immune deficiency is not frequent but could influence the prognosis. Therefore immune explorations should be well codified.

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“…CT findings include consolidation, ground-glass opacities, tree-inbud pattern, centrilobular or random nodules, bronchiectasis, septal thickening, air trapping, or scarring. Complications such as abscess formation, empyema, or lung fibrosis may also be found and are quite unique to CGD where contiguous spread to the chest wall and associated osteomyelitis of ribs and vertebrae may occur (Towbin and Chaves 2010;Mahdaviani et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Imaging in patients with chronic granulomatous disease

Murguía-Favela

MansonDavid

2014

LymphoSign Journal

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Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any of the subunits of nicotinamide adenine dinucleotide phosphate oxidase complex, required for proper phagocyte killing of bacteria and fungi. Most of the cases are X-linked, but autosomal recessive cases have also been identified. Patients suffer from recurrent, life-threatening infections and granulomatous inflammation of the skin, lymph nodes, lungs, liver, spleen, brain, and bones. CGD can be cured by hematopoietic stem cell transplantation. Imaging studies such as radiography, ultrasound, computed tomography, and magnetic resonance imaging play a key role in identifying the changes driven by both infection and dysregulated inflammation. These studies are critical for guiding management of this disorder. We present the most illustrative images from 7 patients with CGD.

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Pulmonary manifestations of chronic granulomatous disease

Cited by 51 publications

References 56 publications

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

Pediatric recurrent respiratory tract infections: when and how to explore the immune system? (About 53 cases)

Imaging in patients with chronic granulomatous disease

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