Pulmonary intravascular macrophages: their contribution  to the mononuclear phagocyte system in 13 species

Brain, Joseph D.; Molina, Ramon M.; DeCamp, Malcolm M.; Warner, Angeline E.

doi:10.1152/ajplung.1999.276.1.l146

Cited by 95 publications

(115 citation statements)

References 23 publications

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“…A caveat with our approach is that we cannot exclude the possibility that clodronate liposomes might deplete other rare cell types. For example, others have described the existence of pulmonary intravascular macrophages, which-similar to Kupffer cells in the liver-play a role in the phagocytosis of large particles such as cellular debris (28,29). Although these cells are far less prevalent in mice than in other species, they could potentially capture clodronate liposomes from the circulation.…”

Section: Discussionmentioning

confidence: 99%

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

Kreisel

Nava²,

Li³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

335

345

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Immune-mediated pulmonary diseases are a significant public health concern. Analysis of leukocyte behavior in the lung is essential for understanding cellular mechanisms that contribute to normal and diseased states. Here, we used two-photon imaging to study neutrophil extravasation from pulmonary vessels and subsequent interstitial migration. We found that the lungs contained a significant pool of tissue-resident neutrophils in the steady state. In response to inflammation produced by bacterial challenge or transplant-mediated, ischemia-reperfusion injury, neutrophils were rapidly recruited from the circulation and patrolled the interstitium and airspaces of the lung. Motile neutrophils often aggregated in dynamic clusters that formed and dispersed over tens of minutes. These clusters were associated with CD115 + F4/80 + Ly6C + cells that had recently entered the lung. The depletion of blood monocytes with clodronate liposomes reduced neutrophil clustering in the lung, but acted by inhibiting neutrophil transendothelial migration upstream of interstitial migration. Our results suggest that a subset of monocytes serve as key regulators of neutrophil extravasation in the lung and may be an attractive target for the treatment of inflammatory pulmonary diseases.lung | two-photon microscopy | transendothelial migration | ischemia | transplant

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Section: Discussionmentioning

confidence: 99%

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

Kreisel

Nava²,

Li³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

335

345

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“…The same process may be occurring in the swine when exposed to PFC resulting in an inflammatory response in the microvasculature resulting in acute lung injury. [22][23][24] Recent preliminary experiments in our laboratory have utilized another PFC (Perflutel RM 101, Miteni, Milan, Italy). This PFC is compatible with biologic use and was utilized in small animal models (rabbits) of TLV by Tissier et al 8 where it did not cause lung toxicity.…”

Section: Discussionmentioning

confidence: 99%

Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model

et al. 2008

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“…On entering the interstitium of the lung they undergo a series of maturational stages before transferring to the surface (e.g. van Furth, 1970;Bowden and Adamson, 1980;Blussé van Oud Alblas et al, 1983;Bowden, 1987;Sebring and Lehnert, 1992;Brain et al, 1999;Geiser, 2010). The turnover time of the PSMs is ~6 days and amounts to 15.10 3 cells per hour (Blussé van Oud Alblas et al, 1983).…”

Section: Pulmonary Surface (Free) Macrophages (Psms)mentioning

confidence: 99%

“…Warner and Brain 1990;Warner, 1996;Brain et al, 1999) and since they are relatively less accessible for experimentation, the cells have not been as well-studied as the PSMs. Regarding their secretory, endolytic, and functional properties, PIVMs are a relatively newly identified constituent of the mononuclear phagocyte system.…”

Section: Pulmonary Intravascular Macrophages (Pivms)mentioning

confidence: 99%

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Cellular Defences of the Lung: Comparative Perspectives

Maina¹

2012

Respiratory Diseases

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'Our lungs are highly complex organs that are exquisitely specialized for gas exchange and host defense.' Rawlins (2010) 1. Introduction General considerationsThe most important function of the lung is to acquire molecular oxygen and eliminate carbon dioxide. Except probably for the gastrointestinal system, no other organ in the body interacts with the external environment as constantly and as intimately as the respiratory system. For example, during a 24 hour period, at rest, the human lung is ventilated ~25,000 times with ~20,000 L of air (e.g. Burri, 1985; Brain, 1996), it has a respiratory surface area (RSA) of ~140 m 2 (about the size of a tennis court) which is located in the acini that lie no more than 40 to 50 cm from the external environment (air) (e.g. Weibel, 1984), and the thickness of the blood-gas (tissue) barrier (BGB) (harmonic mean thickness, ht) is 0.62 μm, a value about one-fiftieth of the thickness of a foolscap paper or that of a human head hair (Gehr et al., 1978(Gehr et al., , 1990a. By weight, each day, more than 20 kg of air enters and leaves the human body, a load that far exceeds that of food and water ingested during the same time period (Brain, 1996). Depending on the level of air pollution, different types and quantities of foreign particulates and microbial pathogens are inhaled. While large RSA and thin BGB increase gas exchange, the concomitant downside to these structural properties is that they make the lung a leading portal of entry and therefore attack by pathogenic micro-organisms, damage by allergens and particulates, and injury by noxious gases (e.g. Brain, , 1992Lambrecht et al. 2001;Garn et al., 2006). The inhaled particulates are deposited on the epithelial lining of the conducting airways and that of the peripheral air spaces where they are retained for various durations before they are removed or destroyed (e.g. Geiser et al., 1988; Gehr et al., 1990 a, b). Brain (1996) observed that 'the lung is unique in that the marriage between environment and lung disease is profound. The respiratory system threfore forms a huge challenge to the body's immune integrity (e.g. von Garnier and Nicod, 2009 , 1993;Schwartz, 1994;Brunekreef et al., 1995;Ware, 2000;Pope, 2000;Nemmar et al., 2002;Pope et al., 2002;Suwa et al., 2002;Schulz et al., 2005;Kaufman, 2010;Brook et al., 2010; van den Hooven et al., 2011;Kampfrath et al., 2011 gc.ca/ccdpc-cpcmc/crdmrc/facts_gen_e.html). According to the Canadian Lung Association (CLA), the economic burden of respiratory disease in the Country is ~3 billion ($US) dollars (http://www.bukisa.com/articles/455926_lung-health-occupational-healthincidence#ixzz1I4jwMvBX). Based on net changes in gross domestic product (GDP) growth forecasts, the estimated annual cost of SARS (Sudden Avian Respiratory Syndrome) in Asia exceeds 10 billion dollars ($US) (Lee and McKibbin, 2003;Fan, 2003;McKibbin and Sidorenko, 2006) and according to the World Bank's estimates, an influenza pandemic may result in a loss (expenditure) of 800 billion dollars ($US) (Brahm...

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Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species

Cited by 95 publications

References 23 publications

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model

Cellular Defences of the Lung: Comparative Perspectives

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