Pulmonary function tests, high-resolution computerized tomography, α1-antitrypsin measurement, and early detection of pulmonary involvement in patients with systemic sclerosis

Shahin, Amira A.; Sabri, Youssriah Yahia; Mostafa, Hisham; Sabry, E.Y.; Hamid, Magdy Abdel; Gamal, Hany; Shahin, Hesham A.

doi:10.1007/s002960000089

Cited by 19 publications

(19 citation statements)

References 17 publications

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“…Other relevant causes of SSc include pulmonary ®brosis. In fact, no signi®cant correlation was observed between the degree of dyspnea and high-resolution computed tomography (HRCT) score, lung volumes, or DLco, as those same patients were already enrolled in another study where those investigations were performed and proved negative [20].…”

Section: Discussionmentioning

confidence: 91%

Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function

Shahin¹,

Anwar

Elawar

et al. 2000

Rheumatology International

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The objective of this paper is to investigate the relation between circulating soluble adhesion molecules and cardiac involvement, as assessed by echocardiography in patients with systemic sclerosis (SSc). Nineteen patients with SSc were submitted for assessment of serum levels of circulating soluble intercellular adhesion molecules (sICAM-1), and soluble vascular cell adhesion molecules-1 (sVCAM-1), and echocardiography. Abnormal left ventricular filling patterns (down E/A ratio) were detected in ten patients (52.6%) with significant negative correlation with sVCAM-1 (r = -0.484, P < 0.05). It was also significantly correlated with age (r = -0.791, P < 0.01), age of onset (r = -0.468, P < 0.05), degree of dyspnea (r = -0.687, P < 0.01), and erythrocyte sedimentation rate (ESR) (r = -0.489, P < 0.05). Our findings suggest an important role for sVCAM-1 as a marker of disease severity and impaired left ventricular filling pattern in SSc.

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Section: Discussionmentioning

confidence: 91%

Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function

Shahin¹,

Anwar

Elawar

et al. 2000

Rheumatology International

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“…Semi-quantitative scores were not used to evaluate progression in this case [27]. Variations of this method also used by Pignone et al [2]; Davas et al [10]; Shahin et al [11]; Giacomelli et al [12]; Shah et al [13]; Gohari Moghadam [14]. …”

Section: Semi-quantitative Scoringmentioning

confidence: 99%

“…Studies using comparative scoring methods found correlation between higher HRCT severity grades and low DLCO, low FVC and low TLC [2,11,14]. When compared to biopsy specimen, mixed groundglass and reticular thickening (HRCT grade 3) corresponded to more inflammatory changes on histopathology.…”

Section: Validitymentioning

confidence: 99%

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Assayag¹,

Kaduri²,

Hudson³

2012

Rheumatology

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Interstitial lung disease commonly develops in patients with Systemic sclerosis (SSc). High resolution computed tomography (HRCT) has become the gold standard for detection and evaluation of lung involvement in SSc. Several HRCT scoring methods have been described and used to characterize and quantify the disease. This article reviews the different scoring systems and how they have been validated clinically and applied to prognosticate patients, assess disease progression and evaluate response to treatment.

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“…However, the advent of highresolution computed tomography (HRCT) has allowed a high sensitive examination of the entire lung parenchyma and pleura in many rheumatic diseases including AS [12][13][14][15]. Furthermore, it was demonstrated that HRCT of the thorax has a diagnostic superiority over plain radiography in the assessment of early pulmonary lesions [16,17].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary abnormalities on high-resolution computed tomography in ankylosing spondylitis: relationship to disease duration and pulmonary function testing

et al. 2011

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The aim of this study was to identify the pulmonary abnormalities on high-resolution computed tomography (HRCT) in patients with ankylosing spondylitis (AS) and to examine the relationship with the duration of disease and pulmonary function test (PFT) results. Twenty male AS patients with a mean age of 37.1 ± 9.4 years were enrolled in this study. The patients were assigned into 2 groups according to disease duration: patients with disease duration <10 years (n = 10) and ≥ 10 years (n = 10). All patients underwent clinical examination, PFT and HRCT. HRCT revealed abnormalities in 14 patients (70%). The most common findings were apical fibrosis (45%) and emphysema (25%). HRCT findings were more prominent in late AS patients (disease duration ≥ 10 years) (P = 0.015). PFT were considered as abnormal in 4 patients (20%). While 3 patients had a restrictive type pulmonary deficiency, one patient had a mild obstructive pattern. Three of these patients had concomitant HRCT abnormalities. On the other hand, 10 patients with normal PFT had abnormalities on HRCT. These findings suggest that pulmonary involvement in AS patients without respiratory symptoms could be sensitively detected by HRCT. However, the clinical significance of these radiological abnormalities should be examined in further prospective studies.

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Pulmonary function tests, high-resolution computerized tomography, α1-antitrypsin measurement, and early detection of pulmonary involvement in patients with systemic sclerosis

Cited by 19 publications

References 17 publications

Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function

Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Pulmonary abnormalities on high-resolution computed tomography in ankylosing spondylitis: relationship to disease duration and pulmonary function testing

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