Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome

Schelling, G.; Scheffold, Christian; Vogelmeier, C. Franz; Hummel, Theresia; Behr, Jüergen; Kapfhammer, Hans-Peter; Rothenhäusler, Hans-Bernd; Haller, M.; Durst, K.; Krauseneck, Till; Briegel, Josef

doi:10.1007/s001340051342

Cited by 153 publications

(138 citation statements)

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“…30 At 5 y after discharge from ICU, ARDS survivors have impairment in all SF-36 health dimensions, with reductions of 25% in physical function and physical role function, 17.5% in general health, and a smaller but statistically significant decrease in psychosocial functioning compared with the general population. 13 Similarly, at 5 y, Herridge et al 38 reported that even relatively young subjects with few coexisting illnesses who survived ARDS had a persistently reduced physical HRQOL in terms of SF-36 score, although those who were younger than 52 y showed a significant improvement in the physical component score from discharge to 5 y, when compared with subjects older than 52 y.…”

Section: Health-related Quality Of Lifementioning

confidence: 98%

“…[43][44][45] However, we know that there is a correlation between pulmonary dysfunction and long-term HRQOL, as indicated in several reports. 13,15,16,23 The severity of the initial acute lung injury/ARDS and the rapidity of its resolution seem to correlate significantly with long-term (1-y) physical function, although the inability to exercise in terms of muscle wasting and weakness has a multifactorial etiology and can be due to extrapulmonary disease. 21 Similarly, ARDS subjects treated with ECMO suffered a loss of HRQOL because of pulmonary sequelae at 1 y after ECMO.…”

Section: Health-related Quality Of Lifementioning

confidence: 99%

“…[10][11][12] However, patients who survive ARDS remain at risk for mortality and may have persistent morbidity. [13][14][15][16][17][18] This article will review the long-term outcomes after ARDS, focusing on mortality, health-related quality of life (HRQOL), neuropsychological disability, radiological findings, and pulmonary dysfunction (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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What's Next After ARDS: Long-Term Outcomes

et al. 2016

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SummaryARDS is a life-threatening organ failure due to several pulmonary and extrapulmonary injuries with an incidence between 5 and 60 cases/100,000 persons/y. Patients with ARDS have non-cardiogenic pulmonary edema and dyspnea often requiring invasive mechanical ventilation and intensive care admission. Although the short-term mortality rate has significantly decreased in the last decade, mainly due to the widespread application of lung-protective ventilation and better general support, long-term outcomes are still unsatisfactory. Besides simply evaluating the outcome at hospital discharge, several recent studies have assessed the health-related quality of life, neuropsychological disability, radiological findings, and pulmonary dysfunction up to 5 y. This paper reviews the literature regarding the long-term outcomes in patients with ARDS. Key words: ARDS; long-term outcomes; health-related quality of life; neuropsychological disability; pulmonary function; lung imaging. [Respir Care 2016;61(5):689 -699.

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Section: Health-related Quality Of Lifementioning

confidence: 98%

Section: Health-related Quality Of Lifementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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What's Next After ARDS: Long-Term Outcomes

et al. 2016

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“…The pulmonary function studies show a mild degree alteration in spirometrical parameters, volumes and DLCO with a predominantly restrictive pattern [18].…”

Section: Discussionmentioning

confidence: 97%

Pulmonary Diffusion Capacity and Quality of Life during a Period of 6 Years in Patients who Survived Acute Respiratory Distress Syndrome

Le¹,

Laime²,

Fiore³

et al. 2017

Intern Med

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“…1 Some of these patients experience a pro-longed stay in ICU (Ͼ7 d) and long and difficult time of mechanical ventilation (Ͼ20 d). 1 These patients have limited clinical outcomes 2 and may suffer depression or anxiety, [3][4][5] with decreased health-related quality of life (HRQOL) 6,7 in the months following intensive care. Indeed, patients continue to require health-care services, but few of them are transferred to rehabilitation facilities.…”

Section: Introductionmentioning

confidence: 99%

Impact of Clinical and Quality of Life Outcomes of Long-Stay ICU Survivors Recovering From Rehabilitation on Caregivers' Burden

et al. 2016

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BACKGROUND: The objective of this work was to evaluate the time course of clinical and healthrelated quality of life outcomes of long-stay ICU survivors' and caregivers' burden. METHODS: The study included 23 subjects of mixed diagnosis (66 ؎ 11 y, body mass index 26.5 ؎ 5.6 kg/m 2 ) with a recent episode of acute respiratory failure needing in-hospital rehabilitation. Subjects and caregivers were evaluated at hospital discharge (T0, n ‫؍‬ 23) and 6 months later (T6, n ‫؍‬ 16). At T0 and T6, subjects' clinical status (Dependence Nursing Scale), FVC (percent-of-predicted FVC and percent-of-predicted FEV), maximum inspiratory/expiratory pressures, effort tolerance (sitto-stand, Takahashi test, 6-min walking distance), and disability (Barthel index) were evaluated. EuroQol-5D (EQ-5D), McGill Quality of Life, General Perceived Self-Efficacy Scale, and Hospital Anxiety and Depression Scale (HADS-A/HADS-D) were assessed. Caregivers' burden was measured by the Family Strain Questionnaire short form and Caregiver Needs Assessment. Correlation between subjects' clinical status and caregiver assessments was performed at T0. RESULTS: At T0, subjects showed compromised EQ-5D index (0.42 ؎ 0.28); 69% of caregivers had high Family Strain Questionnaire and moderate Caregiver Needs Assessment scores (30 ؎ 13). EQ-5D index was significantly related to Dependence Nursing Scale score (P < .001), percent-of-predicted FVC (P < .02), effort tolerance (all P < .01), disability (P < .001), and caregiver Family Strain Questionnaire score (P < .02). At T6, subjects significantly improved percent-of-predicted FVC (P < .05), maximum expiratory pressure (P < .01), effort tolerance (all P < .05), disability (P < .02), and EQ-5D index (P < .05), whereas caregivers' burden scores were unchanged. However, the percentage of caregivers with strain increased. CONCLUSIONS: In prolonged-ICU-stay survivors, EQ-5D index at hospital discharge is related to clinical status and caregivers' strain. Subjects' clinical status and EQ-5D index improves over time, but caregivers' burden remains high, suggesting the need to monitor/support caregivers.

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Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome

Abstract: Long-term survivors of ARDS have a significant reduction in HRQL and the presence of multiple PF impairments is associated with maximal decrements in HRQL.

Cited by 153 publications

References 0 publications

What's Next After ARDS: Long-Term Outcomes

What's Next After ARDS: Long-Term Outcomes

Pulmonary Diffusion Capacity and Quality of Life during a Period of 6 Years in Patients who Survived Acute Respiratory Distress Syndrome

Impact of Clinical and Quality of Life Outcomes of Long-Stay ICU Survivors Recovering From Rehabilitation on Caregivers' Burden

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