“…Because fat embolism during orthopaedic surgery is common, whereas FES is rare, and some patients with fat embolism develop FES, whereas others do not, several risk factors and intrinsic metabolic changes can predispose patients with fat embolism to FES 21 . Reduced cardiorespiratory reserve, hypovolemia, oste-oporosis, and possibly the female sex have all been identified as risk factors for developing FES 6,12,14,22 . FES is diagnosed on the basis of several clinical and laboratory criteria (Table I) [23][24][25] .…”