Pulmonary embolism with junctional tachycardia: A serious complication after COVID-19 vaccination

Miri, Chaymae; Bouchlarhem, Amine; Boulouiz, Soumia; Ouafi, Noha El; Bazid, Zakaria

doi:10.1016/j.amsu.2022.103983

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…The PF4 antibody test was positive, with accompanying thrombocytopenia [ 4 ]. In Morocco, a 49-year-old male without an underlying disease was diagnosed with pulmonary embolism 19 days after the second dose of the Pfizer vaccine, but without thrombocytopenia [ 5 ]. In Oman, a 59-year-old woman with diabetes and osteoporosis was diagnosed with pulmonary embolism and deep vein thrombosis seven days after the first dose of the Pfizer vaccine, similarly without thrombocytopenia [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…In Oman, a 59-year-old woman with diabetes and osteoporosis was diagnosed with pulmonary embolism and deep vein thrombosis seven days after the first dose of the Pfizer vaccine, similarly without thrombocytopenia [ 6 ]. In addition, pulmonary embolism after mRNA vaccination has been reported in several countries ( Table 2 ) [ 4 , 5 , 6 , 13 , 14 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…With the recent introduction of COVID-19 vaccination, thrombosis with thrombocytopenia syndrome (TTS) has been reported [ 2 , 3 ], and most of its mechanisms are related to viral vector vaccines. Recent cases of pulmonary embolism after Pfizer vaccination (BNT162b2) have also been reported in several countries, including the United States, Morocco, and Oman [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Embolism after Vaccination with the COVID-19 Vaccine (Pfizer, BNT162b2): A Case Report

Kim

Yoo

2023

Vaccines

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Pulmonary embolism causes pulmonary vascular obstruction and damages circulation, leading to death in serious cases. Various cases of thrombosis have been reported as adverse reactions after vaccination with COVID-19 vaccines, and reliable studies on thrombosis with thrombocytopenia syndrome (TTS) have been confirmed, especially for viral vector vaccines. However, the association with mRNA vaccines has not been proven. We report a case of pulmonary embolism and deep vein thrombosis that occurred after using mRNA COVID-19 vaccines (BNT162b2).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pulmonary Embolism after Vaccination with the COVID-19 Vaccine (Pfizer, BNT162b2): A Case Report

Kim

Yoo

2023

Vaccines

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Tozinameran

2022

Reactions Weekly

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COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy

du Preez,

Lin,

Maguire

et al. 2024

Eur J Clin Investigation

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In this narrative review, we assess the pathophysiology of severe adverse events that presented after vaccination with DNA and mRNA vaccines against COVID‐19. The focus is on the perspective of an undersulfated and degraded glycocalyx, considering its impact on immunomodulation, inflammatory responses, coagulation and oxidative stress. The paper explores various factors that lead to glutathione and inorganic sulfate depletion and their subsequent effect on glycocalyx sulfation and other metabolites, including hormones. Components of COVID‐19 vaccines, such as DNA and mRNA material, spike protein antigen and lipid nanoparticles, are involved in possible cytotoxic effects. The common thread connecting these adverse events is endotheliopathy or glycocalyx degradation, caused by depleted glutathione and inorganic sulfate levels, shear stress from circulating nanoparticles, aggregation and formation of protein coronas; leading to imbalanced immune responses and chronic release of pro‐inflammatory cytokines, ultimately resulting in oxidative stress and systemic inflammatory response syndrome. By understanding the underlying pathophysiology of severe adverse events, better treatment options can be explored.

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Pulmonary embolism with junctional tachycardia: A serious complication after COVID-19 vaccination

Cited by 4 publications

References 16 publications

Pulmonary Embolism after Vaccination with the COVID-19 Vaccine (Pfizer, BNT162b2): A Case Report

Pulmonary Embolism after Vaccination with the COVID-19 Vaccine (Pfizer, BNT162b2): A Case Report

Tozinameran

COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy

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