Pulmonary Changes in Schistosomal Cor Pulmonale *

Sadigursky, Moysés; Andrade, Zilton A.

doi:10.4269/ajtmh.1982.31.779

Cited by 44 publications

(24 citation statements)

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“…In those works in small animals (such as rat and mice), serial sectioning was performed in either whole or part of the hearts for non-thrombosis diseases [30,31]. Serial sectioning method has been also used for detecting pulmonary changes in patients and successfully identified thrombi in lung [32]. In the previous study with lung biopsy [32], a few representative blocks of the lung tissue were embedded and serial sectioned and no comparison between serial versus non-serial section was made [32].…”

Section: Discussionmentioning

confidence: 99%

“…Serial sectioning method has been also used for detecting pulmonary changes in patients and successfully identified thrombi in lung [32]. In the previous study with lung biopsy [32], a few representative blocks of the lung tissue were embedded and serial sectioned and no comparison between serial versus non-serial section was made [32]. To the best of our knowledge, there is no yet any report about serial sectioning of the whole lungs to investigate PTEs, nor any study trying to obtain thrombus volume by serial sectioning method.…”

Section: Discussionmentioning

confidence: 99%

“…Serial sectioning method has been used in histopathological studies either in small sized animals [30,31] and human samples [32]. In those works in small animals (such as rat and mice), serial sectioning was performed in either whole or part of the hearts for non-thrombosis diseases [30,31].…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model

Peng¹,

Li²,

Yu³

et al. 2015

Thrombosis Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model

Peng¹,

Li²,

Yu³

et al. 2015

Thrombosis Research

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“…The early changes evoked by schistosome eggs within small arteries and arterioles are endothelial cell hyperplasia and fibrin deposition. This is then followed by complex fibrin thrombus and revascularization, and then by congestion and dilatation of focal blood vessels, resulting in the formation of plexiform lesions [28,29]. Some reports suggest that extensive remodeling of the pulmonary vessels may be responsible for most of the pathological changes in humans and in mouse models ( Figure 1) [5,16,[30][31][32][33][34].…”

Section: Pulmonary Involvementmentioning

confidence: 99%

Pulmonary vascular disease associated with schistosomiasis

Kolosionek

Crosby

Harhay

et al. 2010

Expert Review of Anti-infective Therapy

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In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature. Overall, the basic biology and understanding of Schistosoma immune responses and their effect on the cardiopulmonary system is limited in both animal and human models, which hinders clinical care and drug development. The inflammatory response to the eggs in the lung appears to contribute to the remodeling of the pulmonary vessels. Portal hypertension caused by parasitemia also appears to contribute to the development of pathophysiologic alterations of the pulmonary vascular bed. Antischistosomal therapy, praziquantel, used for pulmonary hypertension secondary to schistosomiasis usually has no effect, but it is given to prevent further progression of disease. Currently, there are no clinical trials for the treatment of pulmonary vascular disease secondary to schistosomiasis. Specialty drugs such as phosphodiesterase type 5 or tyrosine kinase inhibitors exhibit some interesting activity, yet are prohibitively expensive, lack safety and efficacy studies in schistosomiasis endemic populations, and tend to be limited by safety, efficacy, route of administration and compliance problems.

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“…In Sch-PAH, serum levels of AST, ALT, and bilirubin are usually normal, but the levels of alkaline phosphatase and γ-GT tend to be higher [ 32 ]. Eosinophilia may be present in patients having continuous exposure to the parasite and active infection.…”

Section: Blood Tests and Immunologymentioning

confidence: 99%

Schistosomiasis-Associated Pulmonary Arterial Hypertension

Ferreira

Bandeira

Domingues

2015

Diagnosis and Management of Pulmonary Hypertension

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Schistosomiasis is the third most common endemic disease and has been considered the most common cause of pulmonary arterial hypertension (PAH) in the world. Around 6 % of people with chronic schistosomiasis in endemic areas are affected. Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) is classifi ed by the World Health Organization as group 1 pulmonary arterial hypertension because it has clinical, pathological, and hemodynamic characteristic that are similar to idiopathic pulmonary arterial hypertension. Sch-PAH is a severe disease that affects mainly middle-aged women. Symptoms and signs of right-heart insuffi ciency may be present, such as dyspnea, syncope, and peripheral edema. It has been demonstrated that Sch-PAH has a more benign clinical course and a better survival than idiopathic pulmonary hypertension. There are few reports of any benefi cial effect from specifi c therapy directed toward group 1 PAH in this population of patients. The mechanisms responsible for the development of pulmonary hypertension in patients with schistosomiasis are unknown. There is growing evidence that vessel obstruction and granulomatous reaction to pulmonary embolization of eggs is not the sole mechanism that causes the disease. Further studies are needed to better elucidate the pathogenesis of Sch-PAH and to develop targeted therapies for this devastating disease.

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Pulmonary Changes in Schistosomal Cor Pulmonale *

Cited by 44 publications

References 0 publications

Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model

Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model

Pulmonary vascular disease associated with schistosomiasis

Schistosomiasis-Associated Pulmonary Arterial Hypertension

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