Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice ( Morinda citrifolia L.)

Dussossoy, Emilie; Bichon, Florence; Bony, Emilie; Portet, Karine; Brat, Pierre; Vaillant, Fabrice; Michel, Alain; Poucheret, Patrick

doi:10.1016/j.jep.2016.07.038

Cited by 29 publications

(25 citation statements)

References 39 publications

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“…Dussossoy et al. () verified that NJ also present an anti‐inflamatory effect in oral and intraperitoneal administrations of NJ in vivo on the lung inflammation in ovalbumin (OVA) sensitized Brown Norway rat. Reduction of inflammation occurred by decreasing inflammatory cells in the lung (macrophages, lymphocytes, eosinophils, and neutrophils).…”

Section: Phytotherapic Propertiesmentioning

confidence: 98%

Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

109

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Morinda citrifolia commonly known as noni is a perennial plant originating in Southeast Asia, consumed over 2000 years. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Chemical and nutritional analyzes already performed in M. citrifolia reveal the existence of more than 200 phytochemical substances with bioactive properties such as acids, alcohols, phenols, saccharides, anthraquinones, carotenoids, esters, triterpenoids, flavonoids, glycosides, lactones, iridoids, ketones, lactones, lignans, nucleosides, triterpenides, sterols, and aromatic compounds. The high nutritional value of M. citrifolia may induce therapeutic effects, including antimicrobial and antioxidant properties. The main industrial products from this plant are beverages (juice drinks), powders (from dried fruits), oil (from seeds), and leaf powders. Biological and phytotherapeutic applications of M. citrifolia are promising, but more extensive studies are still required. Thus, this review aims to gather updated and comprehensive information on Morinda citrifolia, discussing its traditional use, biochemical, phytotherapics, and toxicological properties, as well as the recent advances in the processing and standardization of products derived from noni fruit.

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Section: Phytotherapic Propertiesmentioning

confidence: 98%

Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

109

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“…The 1, 5, 15‐tri‐ O ‐methylmorindol, 2‐ O ‐( β ‐D‐glucopyranosyl)‐1‐ O ‐hexanoyl‐ β ‐D‐gluropyranose and 2‐ O ‐( β ‐D‐glucopyranosyl)‐1‐ O ‐octanoyl‐ β ‐D‐gluropyranose demonstrates inhibitory efficacy against 12‐ O ‐tetradecanoylphorbol‐13‐acetate‐induced inflammations (Akihisa et al, ). The noni fruit juice prevented inflammation in ovalbumin‐sensitized Brown Norway rats (Dussossoy et al, , ). The polysaccharides‐rich extract, chloroform fraction and damnacanthal from roots of M. citrifolia showed antiinflammatory activity (Okusada et al, ; Sousa et al, ; Yilmazer et al, ).…”

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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“…(7.4 and 37 mg/kg, one time) reduction of acute and chronic inflammation 46 asthmatic rat model (ovalbumin-induced, n = 8/group) oral (4.6 mL/kg) and i.p. (2.3 mL/kg) (7 days) reduced number of inflammatory cells in bronchoalveolar lavage 47 americanin A (11) HCT116 tumor xenograft mice (n = 6/group) i.p. (5 or 10 mg/kg, 3 times/week for 41 days) tumor volume reduction by 45%–56% 49 Mangosteen α-mangostin HT-29 human colon xenograft mice (n = 18/group) oral, ad libitum (900 mg/kg added to diet, 3 weeks) attenuation of tumor growth, and reduction of apoptotic proteins (BcL-2 and β-catenin) concentrations in tumor mass 67 Black chokeberry CellBerry ® (spray-dried fruit extract) Rats fed fructose-rich diet (n = 6/group) oral, ad libitum (100 or 200 mg/kg BW/d added to drinking water, 6 weeks) reduced cholesterol, blood glucose modulation of adipogenesis and insulin signaling pathways 84 Commercial spray-dried fruit ethanol extract apolipoprotein E knockout mice fed high-fructose diet (n = 10/group) oral, ad libitum (0.005 or 0.05% diet, 4 weeks) reduction of plasma cholesterol improved hepatic and plasma antioxidant function 83 Maqui berry fruit methanol extract ischemia/reperfusion rat model i.p.…”

Section: Açaímentioning

confidence: 99%

“…A pure Costa Rican noni juice sample obtained from the fruit puree inhibited COX-1 and COX-2 in LPS-activated murine macrophages in vitro , 46 and when administered orally and intraperitoneally, it reduced acute and chronic inflammation in rat models of carrageenan-induced paw edema and ovalbumin-triggered asthma, respectively. 46 , 47 Since COX-2 plays a key role in neu-induced carcinogenesis, it was proposed that the anti-inflammatory property of noni could be a possible antitumor mechanism. 45 In an independent study, americanin A ( 11 ) ( Fig.…”

Section: Nonimentioning

confidence: 99%

Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

Benatrehina

Naman

et al. 2018

Journal of Traditional and Complementary Medicine

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In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases. Laboratory studies on açaí have shown both its antioxidant and anti-inflammatory activities in vitro, and more importantly, its neuroprotective properties in animals. Anthraquinones and iridoid glucosides isolated from noni fruit induce the phase II enzyme quinone reductase (QR), and noni fruit juice exhibited antitumor and antidiabetic activities in certain animal models. Antitumorigenic effects of mangosteen in animal xenograft models of human cancers have been attributed to its xanthone content, and pure α-mangostin was shown to display antineoplastic activity in mice despite a reported low oral bioavailability. Work on the less extensively investigated black chokeberry and maqui berry has focused on recent isolation studies and has resulted in the identification of bioactive secondary metabolites with QR-inducing and hydroxyl-radical scavenging properties. On the basis of the safety studies and toxicity case reports described herein, these fruits may be generally considered as safe. However, cases of adulteration found in a commercialized açaí product and some conflicting results from mangosteen safety studies warrant further investigation on the safety of these marketed botanical dietary supplements.

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Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice ( Morinda citrifolia L.)

Cited by 29 publications

References 39 publications

Properties and Applications of Morinda citrifolia (Noni): A Review

Properties and Applications of Morinda citrifolia (Noni): A Review

Indian Morinda species: A review

Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

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