Puerarin for ischaemic stroke

Overview of Cochrane reviews on Chinese herbal medicine for stroke

“…The reviews included in this study were published between 2005 and 2015 and were up to date. Four reviews15, 16, 17, 18 were excluded according to the pre-defined criteria. In all the reviews, only randomized controlled trials (RCTs) and quasi-RCTs were included.…”

“…However, the primary outcomes of only one review 11 was statistically assessed. Out of the eight reviews included in this study, five reviews11, 14, 16, 17, 18 statistically evaluated the improvement of neurological deficit, whereas one review 15 did not use meta-analysis as a statistical approach.…”

Overview of Cochrane reviews on Chinese herbal medicine for stroke

“…The reviews included in this study were published between 2005 and 2015 and were up to date. Four reviews15, 16, 17, 18 were excluded according to the pre-defined criteria. In all the reviews, only randomized controlled trials (RCTs) and quasi-RCTs were included.…”

“…However, the primary outcomes of only one review 11 was statistically assessed. Out of the eight reviews included in this study, five reviews11, 14, 16, 17, 18 statistically evaluated the improvement of neurological deficit, whereas one review 15 did not use meta-analysis as a statistical approach.…”

Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration

“…showed that no significant adverse effects were observed when 600 mg of puerarin was administered intravenously [ 24 ], which was also supported by a study by Liu et al . [ 25 ]. The normal blood volume of the human body is considered to be 4000-5000 ml, and assuming that the blood volume of the subject is 4500 ml, the blood concentration of puerarin after an injection of 600 mg is about 0.133 mg/ml, i.e.…”

“…Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and they have been implicated in a wide variety of biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth and tumor cell metastasis [ 24 ]. LAMA located in chromosome 6q21, encodes the alpha chain isoform laminin, alpha 4 [ 25 ]. LAMA4 is a cancer-treatment target and high expression of LAMA4 is associated with various malignant tumors such as hematologic neoplasm [ 26 ], digestive system neoplasms [ 27 , 28 ] and genitourinary neoplasms [ 29 , 30 ].…”

Puerarin from Pueraria lobate attenuates ischemia‐induced cardiac injuries and inflammation in vitro and in vivo: The key role of miR ‐130a‐5p/ HMGB2 pathway

“…Pue is a major bioactive ingredient extracted from the root of Pueraria lobata that is a traditional Chinese medicine widely used in the treatment of cardiovascular disorders, including ischemia-induced cardiac injuries (Guo et al, 2018;Liu et al, 2016;Xie et al, 2018). The mechanisms underlying the cardio-protective effects of Pue are diverse, including inhibition of mitochondrial permeability transition pore, inhibition of autophagy, and antioxidant effects (Tang et al, 2014(Tang et al, , 2017.…”

Overview of Cochrane reviews on Chinese herbal medicine for stroke

“…The reviews included in this study were published between 2005 and 2015 and were up to date. Four reviews15, 16, 17, 18 were excluded according to the pre-defined criteria. In all the reviews, only randomized controlled trials (RCTs) and quasi-RCTs were included.…”

“…However, the primary outcomes of only one review 11 was statistically assessed. Out of the eight reviews included in this study, five reviews11, 14, 16, 17, 18 statistically evaluated the improvement of neurological deficit, whereas one review 15 did not use meta-analysis as a statistical approach.…”

Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration

“…showed that no significant adverse effects were observed when 600 mg of puerarin was administered intravenously [ 24 ], which was also supported by a study by Liu et al . [ 25 ]. The normal blood volume of the human body is considered to be 4000-5000 ml, and assuming that the blood volume of the subject is 4500 ml, the blood concentration of puerarin after an injection of 600 mg is about 0.133 mg/ml, i.e.…”

“…Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and they have been implicated in a wide variety of biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth and tumor cell metastasis [ 24 ]. LAMA located in chromosome 6q21, encodes the alpha chain isoform laminin, alpha 4 [ 25 ]. LAMA4 is a cancer-treatment target and high expression of LAMA4 is associated with various malignant tumors such as hematologic neoplasm [ 26 ], digestive system neoplasms [ 27 , 28 ] and genitourinary neoplasms [ 29 , 30 ].…”

Puerarin from Pueraria lobate attenuates ischemia‐induced cardiac injuries and inflammation in vitro and in vivo: The key role of miR ‐130a‐5p/ HMGB2 pathway

“…Pue is a major bioactive ingredient extracted from the root of Pueraria lobata that is a traditional Chinese medicine widely used in the treatment of cardiovascular disorders, including ischemia-induced cardiac injuries (Guo et al, 2018;Liu et al, 2016;Xie et al, 2018). The mechanisms underlying the cardio-protective effects of Pue are diverse, including inhibition of mitochondrial permeability transition pore, inhibition of autophagy, and antioxidant effects (Tang et al, 2014(Tang et al, , 2017.…”

Overview of Cochrane reviews on Chinese herbal medicine for stroke

“…The reviews included in this study were published between 2005 and 2015 and were up to date. Four reviews15, 16, 17, 18 were excluded according to the pre-defined criteria. In all the reviews, only randomized controlled trials (RCTs) and quasi-RCTs were included.…”

“…However, the primary outcomes of only one review 11 was statistically assessed. Out of the eight reviews included in this study, five reviews11, 14, 16, 17, 18 statistically evaluated the improvement of neurological deficit, whereas one review 15 did not use meta-analysis as a statistical approach.…”

Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration

“…showed that no significant adverse effects were observed when 600 mg of puerarin was administered intravenously [ 24 ], which was also supported by a study by Liu et al . [ 25 ]. The normal blood volume of the human body is considered to be 4000-5000 ml, and assuming that the blood volume of the subject is 4500 ml, the blood concentration of puerarin after an injection of 600 mg is about 0.133 mg/ml, i.e.…”

“…Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and they have been implicated in a wide variety of biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth and tumor cell metastasis [ 24 ]. LAMA located in chromosome 6q21, encodes the alpha chain isoform laminin, alpha 4 [ 25 ]. LAMA4 is a cancer-treatment target and high expression of LAMA4 is associated with various malignant tumors such as hematologic neoplasm [ 26 ], digestive system neoplasms [ 27 , 28 ] and genitourinary neoplasms [ 29 , 30 ].…”

Puerarin from Pueraria lobate attenuates ischemia‐induced cardiac injuries and inflammation in vitro and in vivo: The key role of miR ‐130a‐5p/ HMGB2 pathway

“…Pue is a major bioactive ingredient extracted from the root of Pueraria lobata that is a traditional Chinese medicine widely used in the treatment of cardiovascular disorders, including ischemia-induced cardiac injuries (Guo et al, 2018;Liu et al, 2016;Xie et al, 2018). The mechanisms underlying the cardio-protective effects of Pue are diverse, including inhibition of mitochondrial permeability transition pore, inhibition of autophagy, and antioxidant effects (Tang et al, 2014(Tang et al, , 2017.…”