Puerarin for acute ischaemic stroke

Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis

“…26 Puerarin, derived from the leguminous plant puerarin, can improve blood circulation and reduce cardiovascular and cerebrovascular diseases. 27 Several studies have identified that puerarin can promote cell apoptosis, restrain cell viability and motility. [28][29][30] In this study, we showed that puerarin could impede the viability, migration, and invasion of bladder cancer cells, and induce apoptosis.…”

Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis

“…26 Puerarin, derived from the leguminous plant puerarin, can improve blood circulation and reduce cardiovascular and cerebrovascular diseases. 27 Several studies have identified that puerarin can promote cell apoptosis, restrain cell viability and motility. [28][29][30] In this study, we showed that puerarin could impede the viability, migration, and invasion of bladder cancer cells, and induce apoptosis.…”

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway

“…The search for alternative anticancer agents has led to renewed interest in traditional medicine ( 25 , 26 ). Puerarin, as a traditional Chinese medicine, has protective effects on the nervous and cardiovascular system and may additionally prevent osteoporosis, inflammation and liver injury ( 14 , 15 , 17 ). Multiple studies have revealed that puerarin induces cell apoptosis, suppresses cell proliferation and increases the chemosensitivity of cancer cells ( 19 – 21 ).…”

“…Although puerarin has already been widely applied in experimental research and clinical trials in China with high efficiency ( 14 , 15 , 17 , 35 , 36 ), limitations exist. The low aqueous solubility and intestinal permeability values may lead to a lower blood concentration following oral administration of puerarin ( 37 ).…”

Effects of puerarin combined with conventional therapy on ischemic stroke

“…It is possible that the isoflavone in puerarin works directly in the cerebrovascular smooth muscle by reducing calcium influx to improve cerebrovascular endothelial cell function ( 16 ). The isoflavone can also activate the body plasmin system, reducing fibrinogen levels and improving the blood supply in the distal cerebral infarction area in ischemic stroke, competitively antagonizing excitatory amino acid neurotoxicity ( 17 ). It is probably as a combination of these functions that puerarin allows the neuron cells of patients to get better blood supply and recover function faster, and as a consequence the quality of life is improved and there is a decrease in the neurological alteration of biochemical markers.…”

Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis

“…26 Puerarin, derived from the leguminous plant puerarin, can improve blood circulation and reduce cardiovascular and cerebrovascular diseases. 27 Several studies have identified that puerarin can promote cell apoptosis, restrain cell viability and motility. [28][29][30] In this study, we showed that puerarin could impede the viability, migration, and invasion of bladder cancer cells, and induce apoptosis.…”

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway

“…The search for alternative anticancer agents has led to renewed interest in traditional medicine ( 25 , 26 ). Puerarin, as a traditional Chinese medicine, has protective effects on the nervous and cardiovascular system and may additionally prevent osteoporosis, inflammation and liver injury ( 14 , 15 , 17 ). Multiple studies have revealed that puerarin induces cell apoptosis, suppresses cell proliferation and increases the chemosensitivity of cancer cells ( 19 – 21 ).…”

“…Although puerarin has already been widely applied in experimental research and clinical trials in China with high efficiency ( 14 , 15 , 17 , 35 , 36 ), limitations exist. The low aqueous solubility and intestinal permeability values may lead to a lower blood concentration following oral administration of puerarin ( 37 ).…”

Effects of puerarin combined with conventional therapy on ischemic stroke

“…It is possible that the isoflavone in puerarin works directly in the cerebrovascular smooth muscle by reducing calcium influx to improve cerebrovascular endothelial cell function ( 16 ). The isoflavone can also activate the body plasmin system, reducing fibrinogen levels and improving the blood supply in the distal cerebral infarction area in ischemic stroke, competitively antagonizing excitatory amino acid neurotoxicity ( 17 ). It is probably as a combination of these functions that puerarin allows the neuron cells of patients to get better blood supply and recover function faster, and as a consequence the quality of life is improved and there is a decrease in the neurological alteration of biochemical markers.…”

Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis

“…26 Puerarin, derived from the leguminous plant puerarin, can improve blood circulation and reduce cardiovascular and cerebrovascular diseases. 27 Several studies have identified that puerarin can promote cell apoptosis, restrain cell viability and motility. [28][29][30] In this study, we showed that puerarin could impede the viability, migration, and invasion of bladder cancer cells, and induce apoptosis.…”

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway

“…The search for alternative anticancer agents has led to renewed interest in traditional medicine ( 25 , 26 ). Puerarin, as a traditional Chinese medicine, has protective effects on the nervous and cardiovascular system and may additionally prevent osteoporosis, inflammation and liver injury ( 14 , 15 , 17 ). Multiple studies have revealed that puerarin induces cell apoptosis, suppresses cell proliferation and increases the chemosensitivity of cancer cells ( 19 – 21 ).…”

“…Although puerarin has already been widely applied in experimental research and clinical trials in China with high efficiency ( 14 , 15 , 17 , 35 , 36 ), limitations exist. The low aqueous solubility and intestinal permeability values may lead to a lower blood concentration following oral administration of puerarin ( 37 ).…”

Effects of puerarin combined with conventional therapy on ischemic stroke

“…It is possible that the isoflavone in puerarin works directly in the cerebrovascular smooth muscle by reducing calcium influx to improve cerebrovascular endothelial cell function ( 16 ). The isoflavone can also activate the body plasmin system, reducing fibrinogen levels and improving the blood supply in the distal cerebral infarction area in ischemic stroke, competitively antagonizing excitatory amino acid neurotoxicity ( 17 ). It is probably as a combination of these functions that puerarin allows the neuron cells of patients to get better blood supply and recover function faster, and as a consequence the quality of life is improved and there is a decrease in the neurological alteration of biochemical markers.…”