Publisher Correction: High-sensitivity imaging of time-domain near-infrared light transducer

Abstract

In the version of this Article originally published, on the left y axis in Fig. 3c the label '50' was incorrect; it should have been '30'. This has now been corrected in the online versions.

Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications

“…The in vivo use of trivalent lanthanide (Ln 3+ )-doped inorganic upconversion nanocrystals (UCNCs) as fluorescent diagnostic and therapeutic agents has been an active and exciting direction of research in the past few years. − By nonlinearly upconverting low-energy near-infrared (NIR) photons into high-energy visible luminescence, Ln 3+ -doped inorganic UCNCs enable deep-tissue excitation and detection of a fluorescence signal in vivo , bringing opportunities to in vivo biological applications with inherent advantages such as high spatial resolution, minimal background interference, and negligible damage to living organisms. − Particularly, for such biological applications, it is highly desirable that the Ln 3+ -doped inorganic UCNCs can biodegrade into systemically clearable products ( e.g. , water-soluble or small-sized nanocomponents of <5.5 nm) − after fulfilling their in vivo diagnostic and therapeutic functions and thus can be harmlessly eliminated from the body of living organisms during a reasonable period of time.…”