Pterygium in Australia: a cost of illness study

Wlodarczyk, John; Whyte, Patti; Cockrum, Paul; Taylor, Hugh R.

doi:10.1046/j.1442-9071.2001.d01-21.x

Cited by 33 publications

(24 citation statements)

References 20 publications

(24 reference statements)

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“…Outro estudo do tipo populacional, realizado na Indonésia, país com características climáticas semelhantes ao Brasil, encontrou prevalência de 10% (10) , valor semelhante ao encontrado neste estudo. A influência da localização geográfica mais próxima da linha do equador, em que o clima quente favoreceria a ocorrência do pterígio, não é corroborada por estudos que observaram que na África (11) e na Austrália (12) a prevalência na população foi muito mais baixa, da ordem de 1,10%. Diante destes dados, a localização geográfica isoladamente não seria determinante para ocorrência de pterígio.…”

Section: Discussionunclassified

“…Isto poderia ser decorrente de efeitos da radiação ultravioleta, devido à correlação existente entre esta condição e o desenvolvimento do pterígio (15)(16) , em que se observou que a radiação solar teria efeitos nocivos cumulativos, principalmente quando a exposição ocorre desde jovens e persiste por duas ou três décadas (15,17) . Com relação ao sexo, a ocorrência de pterígio foi maior entre os homens (10,4%), corroborando com a literatura (1,(12)(13) . Entretanto, estudos brasileiros mostraram acometimento de ambos os sexos, nas mesmas proporções (4) , ou predomínio no sexo feminino (18) .…”

Section: Discussionunclassified

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Prevalência de pterígio no município de Botucatu - Estado de São Paulo, Brasil

Shiratori¹,

Barros²,

Lourenço³

et al. 2010

Arq. Bras. Oftalmol.

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Section: Discussionunclassified

Prevalência de pterígio no município de Botucatu - Estado de São Paulo, Brasil

Shiratori¹,

Barros²,

Lourenço³

et al. 2010

Arq. Bras. Oftalmol.

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“…Although previous studies report individuals from a higher ambient UVR region (Brisbane) spent less time outdoors compared to other regions of Australia including Tasmania, it must be noted that the intensity of UV exposure in Tasmania is lower [233]. The finding of higher CUVAF levels in Brisbane is consistent with previous work by Wlodarczyk et al who reported Queensland as having double the pterygium surgical rate per 100,000 when compared to Tasmania [234]. Thus, pterygium may well be a sensitive indicator of UV exposure, since the cornea focuses peripheral incident light approximately twenty fold onto the usual limbal location of pterygia [224].…”

Section: Discussionsupporting

confidence: 82%

Complex trait genetics: mapping, correlation and causation

Partida¹

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Efforts to understand the genetic aetiology of complex traits have gained a lot of momentum in the last decade. Advancement of next generation sequencing and the ever-decreasing price of genotyping platforms have allowed us to carry out a vast number of genome wide association studies (GWAS). Until relatively recently, GWAS was guided by the common disease -common genetic variation paradigm.However, recent findings and developments have made us look at the bigger picture, including rare genetic variation. In addition, methodological developments are guiding the translation of GWAS findings. For instance, diverse statistical methods can be applied on genetically informative data to estimate the genetic correlation between complex diseases. The latter can have important medical implications, as genetically correlated diseases might be responsive to the same treatments. Also, approaches such as Mendelian randomization (MR) can help investigations of causal factors in disease when is unfeasible to carry out randomized control trials.My focus is on the application of statistical methods in complex trait genetics -I cover a range of phenotypes, ranging from eye disease to cancer.

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“…In particular, the cornea and conjunctiva are exposed to higher levels of UV-B radiation and higher partial pressures of oxygen than most other tissues. The range of UV-associated eye diseases includes ocular surface squamous neoplasia, cataracts and pterygium, with pterygium having the highest incidence and highest associated health cost in Australia (Shoham et al 2008;Wlodarczyk et al 2001). Occasionally, ocular surface squamous neoplasia and invasive squamous cell carcinoma may develop on the basis of a pterygium.…”

Section: Introductionmentioning

confidence: 99%

Peroxiredoxin I and II in Human Eyes

Klebe

Callahan

Power

2013

J Histochem Cytochem.

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SummaryPeroxiredoxin I and II are both 2-Cys members of the peroxiredoxin family of antioxidant enzymes and inactivate hydrogen peroxide. On western blotting, both enzymes appeared as 22-kD proteins and were present in the sclera, retina and iris. Immunohistochemistry showed strong cytoplasmic labeling in the basal cells of the corneal epithelial layer and the corneoscleral limbus. The melanocytes within the stroma of the iris and the anterior epithelial cells of the lens also showed strong cytoplasmic labeling. The fibrous structure of the stroma and the posterior surface of the ciliary body were also labeled. There was also strong labeling for both enzymes in the photoreceptors and the inner and outer plexiform layers of the retina. There was increased labeling of peroxiredoxin I and II in pterygium. In normal conjunctiva and cornea, only the basal cell layer showed labeling for peroxiredoxin I and II, whereas, in pterygia, there was strong cytoplasmic labeling in most cells involving the full thickness of the epithelium. Co-localization of the DNA oxidation product 8-hydroxy-2'-deoxyguanosine antibody with the nuclear dye 4',6'-diamidino-2-phenylindole dihydrochloride indicated that the majority of the oxidative damage was cytoplasmic; this suggested that the mitochondrial DNA was most affected by the UV radiation in this condition. (J Histochem Cytochem 62:85-96, 2014)

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Pterygium in Australia: a cost of illness study

Abstract: The direct medical costs of pterygium in Australia are AUD$8.3 m annually. This is likely to be an underestimate of total cost because indirect costs such as loss of work time could not be measured. More data are needed on the long-term benefits of pterygium intervention.

Cited by 33 publications

References 20 publications

Prevalência de pterígio no município de Botucatu - Estado de São Paulo, Brasil

Prevalência de pterígio no município de Botucatu - Estado de São Paulo, Brasil

Complex trait genetics: mapping, correlation and causation

Peroxiredoxin I and II in Human Eyes

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