Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate

Interaction Studies of a Novel, Water-Soluble and Anti-Cancer Palladim(II) Complex with Calf Thymus DNA

“…14 However, several platinum and palladium dithiocarbamate complexes are known to have been tested in various medical applications. [15][16][17][18][19] In these complexes, the major advantage of using the small bite-angle of dithiocarbamate moiety as a stabilizing chelating ligand is its unique property to remain intact under a variety of reaction conditions. 20 Recently we have reported several dithiocarbamate derivatives of 2,2'-bipyridine-platinum(II)/-palladium(II) complexes.…”

Theoretical study of anticancer drug trans-[Pd(dmnp)2Cl2] binding to DNA purine bases, phosphate group and amino acid residues

“…In addition, the O of phosphate group (P, P = Phosphate) of DNA is considered as potential coordination site. Palladium (II) complexes reacting with DNA base have the similar mechanism to platinum (II) complexes [28][29][30], but studies of Pd (II) complexes are more feasible for their ligand substitution and their rates are typically 10 5 times greater than for Pt(II).…”

Synthesis, characterization and in vitro cytotoxicity of palladium(II) complexes with mixed ligands. X‐ray diffraction study of C31H36ClNPPdS2

“…3,4 The dithiocarbamate derivatives of α-amino acids are another class which acts as a useful model to study the coordination of proteins to metallic cations. 5 The dithiocarbamate derivatives of α-amino acids, in which the NC(S)SH moiety is replaced by NC(S)SR, are able to coordinate to transition metals as terminal or as bridging ligands. 6,7 The chemistry of transition metal-sulfur clusters is now growing rapidly because of their wide range of biological and catalytic applications owing to their similarity to certain biological and industrial catalysts.…”