Psychosocial Factors Associated with Quality of Life in Young Men Who Have Sex with Men Living with HIV/AIDS in Zhejiang, China

Jiang, Tingting; Zhou, Xin; Wang, Hui; Luo, Mingyu; Pan, Xiaohong; Ma, Qiaoqin; Chen, Lin

doi:10.3390/ijerph16152667

Cited by 22 publications

(18 citation statements)

References 43 publications

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“…The results showed there was a significant positive relationship between QoL domain scores and intensities of recovery of HIV-infected patients. Studies conducted in South Africa [52] and China [53] revealed a similar finding where a better QoL score significantly associated with a higher CD4 count.…”

Section: Discussionmentioning

confidence: 54%

Modelling of viral load dynamics and CD4 cell count progression in an antiretroviral naive cohort: using a joint linear mixed and multistate Markov model

et al. 2020

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Background: Patients infected with HIV may experience a succession of clinical stages before the disease diagnosis and their health status may be followed-up by tracking disease biomarkers. In this study, we present a joint multistate model for predicting the clinical progression of HIV infection which takes into account the viral load and CD4 count biomarkers. Methods: The data is from an ongoing prospective cohort study conducted among antiretroviral treatment (ART) naïve HIV-infected women in the province of KwaZulu-Natal, South Africa. We presented a joint model that consists of two related submodels: a Markov multistate model for CD4 cell count transitions and a linear mixed effect model for longitudinal viral load dynamics. Results: Viral load dynamics significantly affect the transition intensities of HIV/AIDS disease progression. The analysis also showed that patients with relatively high educational levels (β = − 0.004; 95% confidence interval [CI]:-0.207, − 0.064), high RBC indices scores (β = − 0.01; 95%CI:-0.017, − 0.002) and high physical health scores (β = − 0.001; 95%CI:-0.026, − 0.003) were significantly were associated with a lower rate of viral load increase over time. Patients with TB co-infection (β = 0.002; 95%CI:0.001, 0.004), having many sex partners (β = 0.007; 95%CI:0.003, 0.011), being younger age (β = 0.008; 95%CI: 0.003, 0.012) and high liver abnormality scores (β = 0.004; 95%CI:0.001, 0.01) were associated with a higher rate of viral load increase over time. Moreover, patients with many sex partners (β = − 0.61; 95%CI:-0.94, − 0.28) and with a high liver abnormality score (β = − 0.17; 95%CI:-0.30, − 0.05) showed significantly reduced intensities of immunological recovery transitions. Furthermore, a high weight, high education levels, high QoL scores, high RBC parameters and being of middle age significantly increased the intensities of immunological recovery transitions. Conclusion: Overall, from a clinical perspective, QoL measurement items, being of a younger age, clinical attributes, marital status, and educational status are associated with the current state of the patient, and are an important contributing factor to extend survival of the patients and guide clinical interventions. From a methodological perspective, it can be concluded that a joint multistate model approach provides wide-ranging information about the progression and assists to provide specific dynamic predictions and increasingly precise knowledge of diseases.

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Section: Discussionmentioning

confidence: 54%

Modelling of viral load dynamics and CD4 cell count progression in an antiretroviral naive cohort: using a joint linear mixed and multistate Markov model

et al. 2020

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“…The US study observed signi cantly lower levels of depression and fewer conduct problems in adolescents whose parents were infected with HIV revealed that with more social support (26). The Chinese study revealed a better QOL among young men who have sex with men living with HIV who had greater social support (27). This domain is believed to be an important component which affected overall QOL.…”

Section: Discussionmentioning

confidence: 97%

Quality of Life and HIV Adherence Self-efficacy of Adolescents and Young Adults Living With Perinatal HIV in Chiang Mai, Thailand: A Cross-sectional Study

Aurpibul

Pradsarakee

Sintupat

et al. 2020

Preprint

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Abstract Background:Currently there are many children with perinatal HIV infection (PHIV) in Thailand who have survived on effective treatment, and grown up into adolescents and young adults (AYA). We determined their quality of life and HIV adherence self-efficacy.Methods: This cross-sectional study was conducted at Research Institute for Health Sciences, Chiang Mai University, Thailand in 2018. Inclusion criteria were: 1) aged between 15-25 years, 2) living with perinatal HIV infection, and 3) receiving ART. Those with mental, physical, or communication problems and could not provide responses independently were excluded. The WHO-quality of life-BREF questionnaire and the HIV Treatment Adherence Self-Efficacy Scale (HIV-ASES) were usedin collecting data by self-administered questionnaires on mobile device.Results: A hundred and eleven AYA-PHIV were included; 52 (47%) were female. Their median age, and duration on ART were 20.2 (IQR 18.2-22.6), and 14.1 (IQR 10.4-14.8) years, respectively. Approximately half (59.4%) of AYA-PHIV rated their overall QOL as favorable (41.4% good,and 18.0% very good), whereas 35.1%rated as neither poor nor good. The mean ± SD domain-wise scores were 54.71 ± 10.80, 59.79 ± 13.17, 63.19 ± 20.56, and 65.32 ± 16.74inthe physical health, psychological health,social relationship, and environmental health, respectively. The overall mean HIV–ASES score was 7.79 ±1.95, with a trend towards higher scores in female than male AYA-PHIV. A positive correlation between HIV-ASES and QOL was observed (r=0.268, p=0.005).Conclusion: Most of AYA-PHIVin Thailand had a favorable QOL and optimal HIV-adherence self-efficacy.Attention should be paid on strengthen their physical and psychological health, with continuous social support. Intervention to boost their HIV-adherence self-efficacy when entering adult life is warranted.

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“…Higher mortality among older males may be attributed to their late diagnosis, comorbidities, and poor immunological responses to ART [ 28 , 29 ]. Educational level was negatively associated with AIDS-related mortality, probably because individuals with high education were more likely to adopt protective measures than others [ 30 , 31 ]. Lower AIDS-related mortality risk was observed among married patients, which related with fewer sexual partners [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of antiretroviral therapy initiation time and baseline CD4⁺cell counts on AIDS-related mortality among former plasma donors in China: a 21-year retrospective cohort study

Yang

Zhang

et al. 2021

Global Health Action

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Background The conventional survival analysis model on HIV/AIDS prognosis is the Cox proportional hazard model, which deals with only one event type, death, regardless of the cause. Few studies have used a competing risk model to evaluate the predictors of AIDS-related mortality. Objective To estimate the influence of antiretroviral therapy (ART) initiation time and baseline CD4 + cell counts on acquired immunodeficiency syndrome (AIDS)-related death among former plasma donors. Methods A retrospective cohort study was conducted involving 11,905 human immunodeficiency virus (HIV) or AIDS patients in a high-risk area of Henan province in China between 1995 and 2016. Demographic and clinical data were collected. Sub-distribution hazard ratios ( sHRs ) for AIDS-related mortality with baseline CD4 + cell counts and ART initiation time were determined using a competing risk model. Results Patients who initiated ART within 90 days of HIV/AIDS diagnosis ( sHR : 0.24, 95% CI : 0.22–0.27) or had baseline CD4 + counts of >500 cells/μL ( sHR : 0.23, 95% CI : 0.19–0.28) were associated with lower AIDS-related mortality risk. Patients with ART initiation time >1 year but CD4 + counts >350 cells/μL ( sHR : 4.42, 95% CI : 3.30–5.91) had a higher AIDS-related mortality risk than those with ART initiation time >90 days but CD4 + counts ≤350 cells/μL ( sHR : 4.33, 95% CI : 3.58–5.23). Conclusions Our results demonstrate that patients with high CD4 + cell counts and late ART had a 9% higher risk of AIDS-related death than those with low CD4 + cell counts and early ART. This study confirms the great significance of immediate ART initiation among former plasma donor HIV patients in China.

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Psychosocial Factors Associated with Quality of Life in Young Men Who Have Sex with Men Living with HIV/AIDS in Zhejiang, China

Cited by 22 publications

References 43 publications

Modelling of viral load dynamics and CD4 cell count progression in an antiretroviral naive cohort: using a joint linear mixed and multistate Markov model

Modelling of viral load dynamics and CD4 cell count progression in an antiretroviral naive cohort: using a joint linear mixed and multistate Markov model

Quality of Life and HIV Adherence Self-efficacy of Adolescents and Young Adults Living With Perinatal HIV in Chiang Mai, Thailand: A Cross-sectional Study

Effect of antiretroviral therapy initiation time and baseline CD4⁺cell counts on AIDS-related mortality among former plasma donors in China: a 21-year retrospective cohort study

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Psychosocial Factors Associated with Quality of Life in Young Men Who Have Sex with Men Living with HIV/AIDS in Zhejiang, China

Cited by 22 publications

References 43 publications

Modelling of viral load dynamics and CD4 cell count progression in an antiretroviral naive cohort: using a joint linear mixed and multistate Markov model

Modelling of viral load dynamics and CD4 cell count progression in an antiretroviral naive cohort: using a joint linear mixed and multistate Markov model

Quality of Life and HIV Adherence Self-efficacy of Adolescents and Young Adults Living With Perinatal HIV in Chiang Mai, Thailand: A Cross-sectional Study

Effect of antiretroviral therapy initiation time and baseline CD4+cell counts on AIDS-related mortality among former plasma donors in China: a 21-year retrospective cohort study

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Effect of antiretroviral therapy initiation time and baseline CD4⁺cell counts on AIDS-related mortality among former plasma donors in China: a 21-year retrospective cohort study