“…While data from the literature generally support the higher frequency of some psychiatric abnormalities in IBS patients, mainly anxiety and depression (42,43), their correlation with the outcome is controversial; some authors argue that their capability in predicting outcome is poor (34,44), whereas others have found a strong correlation between psychological factors and patient outcome (45)(46)(47). Furthermore, psychological factors are believed to be strong indicators of health care seeking by some (34,48) but not all authors (49,50).…”