Psychometric Properties and Validation of the Standard Patient Evaluation of Eye Dryness Questionnaire

Ngo, William; Situ, Ping; Keir, Nancy; Korb, Donald R.; Blackie, Caroline A.; Simpson, Trefford

doi:10.1097/ico.0b013e318294b0c0

Cited by 222 publications

(199 citation statements)

References 37 publications

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“…As reported in a multicenter clinical study, a single TPS treatment resulted in sustained improvement in both signs and symptoms of evaporative DED secondary to MGD at 1 month posttreatment. [16][17][18] Furthermore, observational follow-up studies using different subcohorts of patients from the original multicenter study 18 revealed sustained improvement in both signs (meibomian gland secretion [MGS] scores and, in some cases, tear film breakup time [TBUT]) and symptoms (Ocular Surface Disease Index [OSDI] 19 and Standard Patient Evaluation of Eye Dryness [SPEED] 20,21 questionnaire scores) at 9 22 and 12 months 23 post-TPS treatment when compared with the original 1-month posttreatment data. These TPS treatment results demonstrate an unprecedented duration of treatment benefits for patients suffering from evaporative dry eye secondary to MGD.…”

mentioning

confidence: 99%

Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms

Greiner

2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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mentioning

confidence: 99%

Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms

Greiner

2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…During the clinical examination, patients were required to complete five of the most common Dry Eye Questionnaires used in the clinical setting: The Ocular-surfacedisease-index (OSDI) [30], Mcmonnies (MQ) [31], the standard patient evaluation of eye dryness (SPEED) [32], the Symptom Assessment in Dry Eye (SANDE) [33] and the Dry Eye Questionnaire (DEQ-5; short version) [34].…”

Section: Symptomatology Assessmentmentioning

confidence: 99%

The effect of ageing on the ocular surface parameters

Rico-del-Viejo

Lorente‐Velázquez

Hernández-Verdejo

et al. 2018

Contact Lens and Anterior Eye

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“…Patient symptom severity scores from the OSDI [17][18][19] and Standard Patient Evaluation of Eye Dryness (SPEED) questionnaires were also reviewed. 20 IVCM images of the palpebral conjunctiva and central cornea were then analyzed by two masked observers.…”

Section: Study Design and Patient Populationmentioning

confidence: 99%

In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms: a pilot study

Qazi

Kheirkhah

Blackie

et al. 2015

Eye

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Purpose The utility of in vivo confocal microscopy (IVCM) in the investigation of palpebral conjunctival and corneal inflammation in patients with meibomian gland dysfunction (MGD)-associated refractory dry eye symptoms following gland expression, despite objective clinical improvement. Methods A retrospective, observational pilot study was conducted evaluating five patients with MGD-associated refractory dry eye symptoms and three control groups: symptomatic untreated MGD patients (n = 3), treatment-responsive MGD patients with improved symptoms (n = 3) and asymptomatic healthy normals (n = 11). Ocular surface disease index (OSDI) scores, tear break-up time (TBUT), the number of meibomian glands yielding liquid secretion (MGYLS), palpebral conjunctival epithelial and substantia propria immune cell (EIC, SIC), and corneal dendritic cell (DC) densities were measured. Results Despite clinical improvement (TBUT: 6.4 ± 1.2 s to 10.1 ± 2.1 s, P = 0.03; MGYLS: 3.5 ± 0.8 glands to 7.0 ± 1.1 glands, P = 0.13) and a normal clinical examination post treatment, MGD patients remained symptomatic. IVCM revealed increased immune cells in the palpebral conjunctiva (refractory MGD EIC = 592.6 ± 110.1 cells/ mm 2 ; untreated MGD EIC = 522.6 ± 104.7 cells/mm 2 , P = 0.69; responsive MGD EIC = 194.9 ± 119.4 cells/mm 2 , Po0.01; normals EIC = 123.7 ± 19.2 cells/mm 2 , Po 0.001), but not the cornea (refractory MGD DC = 60.9 ± 28.3 cells/mm 2 ; normals DC = 25.9 ± 6.3 cells/mm 2 ; P = 0.43). EIC did not correlate with TBUT (R s = − 0.26, P = 0.33). OSDI scores correlated with both EIC (R s = 0.76, Po0.001) and TBUT (R s = − 0.69, Po0.01) but not SIC. Intraglandular immune cells were also seen. Conclusion MGD-associated refractory symptoms and the symptom-sign disparity may be explained by clinically non-apparent, active inflammation of the palpebral conjunctiva as detected by IVCM. These patients may benefit from anti-inflammatory therapy.

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Psychometric Properties and Validation of the Standard Patient Evaluation of Eye Dryness Questionnaire

Abstract: The SPEED questionnaire was shown to be a repeatable and valid instrument for measurement of dry eye symptoms. The SPEED score also correlated significantly with ocular surface staining and clinical measures of meibomian gland function.

Cited by 222 publications

References 37 publications

Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms

Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms

The effect of ageing on the ocular surface parameters

In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms: a pilot study

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