Objectives
This study evaluated the utility of Patient-Reported Outcomes Measure Information System Depression Scale (PROMIS-8a) compared to selected “Legacy” depression scales including Montgomery-Asberg Depression Rating Scale (MADRS), Geriatric Depression Scale (GDS), and GDS-Short Form (GDS-SF). Additionally, the measures’ properties were assessed across levels of cognitive functioning.
Methods
This cross-sectional analysis was extracted from a prospective cohort study. PROMIS-8a and Legacy depression measures were administered to individuals aged ≥70 grouped by cognitive status based on the Saint Louis University Mental Status Examination. McNemar tests were run to determine if measures categorized the absence or presence of depression differently and item analysis evaluated classification discrepancies.
Results
Sample mean age was 78, the majority was female (71%), Caucasian (79%), with at least a high-school education (89%). The percentage of individuals with at least mild depression was similar across measures (20.7% PROMIS-8a; 19.0% MADRS; 17.9% GDS; 13.9% GDS-SF). PROMIS-8a total score correlated moderately with MADRS (r=.56, df=295, p<.01), GDS (r=.68, df=291, p<.01), and GDS-SF (r=.60, df=291, p<.01) and predictive validity of the measures was similar. There were no significant mean differences on depression measures by cognitive status.
Conclusions
While all measures identified a similar percent of depressed individuals, the classification differed by measure. Item analysis showed that PROMIS-8a was more likely to identify feelings of dysphoria, and the MADRS and GDS were more likely to identify physiological aspects of depression. Given the brevity and ease of administration of the PROMIS-8a, it appears to be a useful depression screen for community-dwelling older adults.