Psychiatric Manifestations of Pick’s Disease

Abstract

Pick's disease is a rare cause of dementia frequently misdiagnosed as Alzheimer's disease. Because patients with Pick's disease often present with psychiatric symptoms, the psychiatric aspects of this disorder are reviewed, as well as the pathology and epidemiology of the disease. Two case reports illustrate many of the clinical features of PD. A detailed examination of the psychiatric aspects of the disorder is followed by an elucidation of the many clinical differences between Pick's disease and Alzheimer's disease.

Frontal variant of frontotemporal dementia: a cross-sectional and longitudinal study of neuropsychiatric features

“…This study shows that in contrast to some statements in the literature (Jung & Solomon, 1993) patients with FTD do complain of psychiatric symptoms. It does seem, however, that the reported symptoms are shallow, highly variable, evanescent and do not progress over time.…”

Frontal variant of frontotemporal dementia: a cross-sectional and longitudinal study of neuropsychiatric features

“…This study shows that in contrast to some statements in the literature (Jung & Solomon, 1993) patients with FTD do complain of psychiatric symptoms. It does seem, however, that the reported symptoms are shallow, highly variable, evanescent and do not progress over time.…”

Manchester and Oxford University Scale for the Psychopathological Assessment of Dementia

“…Such a scale will, we hope, be useful for several purposes including the differential diagnosis of dementia (Jung & Solomon, 1993;McKeith et al, 1992) as well as the quantification of noncognitive features, which are particularly important for carers, patients, and investigators.…”

The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry

“…2 At the time, PiD could only be diagnosed definitively via autopsy. Presently, however, bvFTD is considered a common form of early-onset neurodegenerative disease, and the clinical and radiographic features of bvFTD have been delineated to allow premortem diagnosis.…”

Frontal variant of frontotemporal dementia: a cross-sectional and longitudinal study of neuropsychiatric features

“…This study shows that in contrast to some statements in the literature (Jung & Solomon, 1993) patients with FTD do complain of psychiatric symptoms. It does seem, however, that the reported symptoms are shallow, highly variable, evanescent and do not progress over time.…”

Manchester and Oxford University Scale for the Psychopathological Assessment of Dementia

“…Such a scale will, we hope, be useful for several purposes including the differential diagnosis of dementia (Jung & Solomon, 1993;McKeith et al, 1992) as well as the quantification of noncognitive features, which are particularly important for carers, patients, and investigators.…”

The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry

“…2 At the time, PiD could only be diagnosed definitively via autopsy. Presently, however, bvFTD is considered a common form of early-onset neurodegenerative disease, and the clinical and radiographic features of bvFTD have been delineated to allow premortem diagnosis.…”

Frontal variant of frontotemporal dementia: a cross-sectional and longitudinal study of neuropsychiatric features

“…This study shows that in contrast to some statements in the literature (Jung & Solomon, 1993) patients with FTD do complain of psychiatric symptoms. It does seem, however, that the reported symptoms are shallow, highly variable, evanescent and do not progress over time.…”

Manchester and Oxford University Scale for the Psychopathological Assessment of Dementia

“…Such a scale will, we hope, be useful for several purposes including the differential diagnosis of dementia (Jung & Solomon, 1993;McKeith et al, 1992) as well as the quantification of noncognitive features, which are particularly important for carers, patients, and investigators.…”

The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry

“…2 At the time, PiD could only be diagnosed definitively via autopsy. Presently, however, bvFTD is considered a common form of early-onset neurodegenerative disease, and the clinical and radiographic features of bvFTD have been delineated to allow premortem diagnosis.…”